Barley Sprout Water Extract and Saponarin Mitigate Triacylglycerol Accumulation in 3T3-L1 Adipocytes

Kim, Hyo-Jin; Lim, Sol; Chung, Sangwon; Lee, Sohee; Choi, Eun Joo; Yang, Kee Heun; Chung, Min‐Yu

doi:10.1089/jmf.2021.k.0092

Cited by 6 publications

(9 citation statements)

References 33 publications

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“…The in vitro and in vivo analysis of the antiobesity effect of SA in YBL extract using 3T3-L1 preadipocytes cell and mice model, respectively, showed that SA could not only suppress adipocyte growth and differentiation, but also mitigate the effects of obesity-related metabolic diseases . Consistently, a recent study using 3T3-L1 preadipocyte cells and mice model revealed that SA administration could significantly block the accumulation of triacylglycerol (TAG) by downregulating the fatty acid synthase (FAS) and decrease the expression level of TAG ( DGAT1 , GPAT , and AGPAT2 ) and FAS ( PPARγ , FAS , C/EBPa , and FABP4 ) related genes in 3T3-L1 adipocytes cells and diet-induced obese mice …”

Section: Biological Roles Of Ybl Derived Saponarinmentioning

confidence: 76%

“…21,22 The bioactive polyphenol SA accumulated in the YBL has been reported to exhibit various pharmacological properties, such as anti-inflammatory response, by modulating cytokines expression, 23,24 lowering the blood sugar level, insulin resistance, postprandial blood glucose control in diabetics, 25,26 hepatoprotective activities against the in vivo and in vitro alcoholinduced liver damage, 27,28 and antiobesity by suppressing the adipocytes growth and differentiation. 29,30 In this review, we first briefly discuss about the natural variation of SA in plants and SA biosynthesis, and subsequently explore the existing studies on SA roles, including responses to environmental stress and therapeutic benefits. Furthermore, we highlight the obstacles and research gaps that remain to overcome in SA use and commercialization.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The role of a bifunctional UGT708A6 C -/ O -glycosyltransferase in catalyzing the synthesis of both C - and O -glycoside from 2-hydroxyflavanones and flavanones, respectively, was previously demonstrated in maize . Despite knowledge on the activation of SA synthesis and activities of their key O -glycosyltransferases ( OGT ) enzymes in response to various environmental factors in YBL, the flavonone intermediate pathway at the internode for the SA percussor molecule, isovitexin synthesis and its enzymatic regulation are yet to be elucidated. , The bioactive polyphenol SA accumulated in the YBL has been reported to exhibit various pharmacological properties, such as anti-inflammatory response, by modulating cytokines expression, , lowering the blood sugar level, insulin resistance, postprandial blood glucose control in diabetics, , hepatoprotective activities against the in vivo and in vitro alcohol-induced liver damage, , and antiobesity by suppressing the adipocytes growth and differentiation. , …”

Section: Introductionmentioning

confidence: 99%

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Saponarin, a Di-glycosyl Flavone from Barley (Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application

et al. 2023

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Saponarin (SA) is a major di-C-glycosyl-O-glycosyl flavone, which is predominantly accumulated in the young green leaves of barley (Hordeum vulgare L.), with numerous biological functions in plants, such as protection against environmental stresses. Generally, SA synthesis and its localization in the mesophyll vacuole or leaf epidermis are largely stimulated in response to biotic and abiotic stresses to participate in a plant’s defense response. In addition, SA is also credited for its pharmacological properties, such as the regulation of signaling pathways associated with antioxidant and anti-inflammatory responses. In recent years, many researchers have shown the potential of SA to treat oxidative and inflammatory disorders, such as in protection against liver diseases, and reducing blood glucose, along with antiobesity effects. This review aims to highlight natural variations of SA in plants, biosynthesis pathway, and SA’s role in response to environmental stress and implications in various therapeutic applications. In addition, we also discuss the challenges and knowledge gaps concerning SA use and commercialization.

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Section: Biological Roles Of Ybl Derived Saponarinmentioning

confidence: 76%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Saponarin, a Di-glycosyl Flavone from Barley (Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application

et al. 2023

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“…In our study, we found significantly increased amounts of saponarin, prunetin, 3- O -acetylpinobanksin, methylhesperidin, and other flavonoids in BsR than in BcR. Saponarin, which is the sole flavonoid present in barley sprout leaves ( Kim et al, 2022 ), possesses potent antioxidant ( Kamiyama and Shibamoto, 2012 ) and hepatoprotective activities ( Simeonova et al, 2013 ), and can be potentially used to prevent and relieve immune-related skin diseases ( Min et al, 2021 ). Prunetin has anti-inflammatory effects ( Abusaliya et al, 2022 ), prevents hepatocellular carcinogenesis by improving functions of the liver ( Li G. et al, 2022 ), and suppresses high-fat diet (HFD)-induced adipogenesis in the liver tissues of mice by regulating gene expression in liver tissue ( Ahn et al, 2013 ).…”

Section: Discussionmentioning

confidence: 75%

Metabolomics Analysis Reveals the Differences Between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd.

et al. 2022

Front. Plant Sci.

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Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. are two varieties of Bupleuri Radix in Chinese Pharmacopoeia 2020. The clinical efficacy of the two bupleurum species is different. The difference in clinical efficacy is closely related to the composition of plant metabolites. In order to analyze the difference in metabolites, we used liquid chromatography coupled with mass spectrometry (LC-MS) for untargeted metabolome and gas chromatography coupled with mass spectrometry (GC-MS) for widely targeted metabolome to detect the roots (R), stems (S), leaves (L), and flowers (F) of two varieties, and detected 1,818 metabolites in 25 classes. We performed a statistical analysis of metabolites. Differential metabolites were screened by fold-change and variable importance in the projection values of the OPLS-DA model, and significant differences were found among different groups. The content of active components (triterpenoid saponins) was found to be high in the BcR group than in the BsR group. Other pharmacological metabolites were significantly different. By Kyoto Encyclopedia of Genes and Genomes annotation and enrichment analysis, we found that differential metabolites of the aboveground parts mainly concentrated in monoterpenoid biosynthesis, while the differential metabolites of the root mainly concentrated in sesquiterpenoid and triterpenoid biosynthesis. Differences in metabolic networks may indirectly affect the metabolic profile of Bc and Bs, leading to differences in clinical efficacy. Our study provides a scientific basis for subsequent biosynthesis pathway and related bioactivity research, and provides a reference for developing non-medicinal parts and guiding the clinical application of Bupleuri Radix.

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“…Obesity can be prevented by regular physical activity, balanced nutrition, and the consumption of healthy foods. A number of studies have provided evidence for obesity-preventing foods, which are mostly plant-based and include garlic (Kagawa et al, 2020), ginger (Seo et al, 2021), tea (Zhou et al, 2022), and edible sprouts (Kim et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta‐analysis

Chung¹,

Park

2023

Food Science & Nutrition

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Onions are rich in bioactive compounds and have been found to prevent various chronic diseases, including obesity. We performed a systematic review and meta‐analysis to investigate the antiobesity effect of onions. Studies were identified in PubMed/MEDLINE, Embase, Web of Science, and CENTRAL focusing on clinical trials evaluating the antiobesity effects of onion in obese subjects. The risk of bias in the studies was evaluated using Cochrane's Risk of Bias tool. The effect of onions was analyzed using data from the selected studies, and the results were indicated by weighted mean difference with 95% CI. The I2 static test was used to examine heterogeneity between the studies. A total of 38 studies were reviewed, of which five clinical trials meeting the criteria were selected. As investigational products, onion peels were used in four studies and onions were used in one study. Following systematic review, it was determined that the risk of bias was generally low, and body weight, BMI, waist circumference, and triglyceride levels were significantly reduced in the onion groups compared to the placebo. In conclusion, onion intake had an antiobesity effect by reducing body weight and body fat, and this effect was particularly pronounced with onion peel.

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Barley Sprout Water Extract and Saponarin Mitigate Triacylglycerol Accumulation in 3T3-L1 Adipocytes

Cited by 6 publications

References 33 publications

Saponarin, a Di-glycosyl Flavone from Barley (Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application

Saponarin, a Di-glycosyl Flavone from Barley (Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application

Metabolomics Analysis Reveals the Differences Between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd.

Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta‐analysis

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