Barnidipine: a new calcium channel blocker for hypertension treatment

Abstract

Although it is commonly agreed that all antihypertensive medications have similar efficacy, there are important differences related to safety, tolerability, patient adherence, cost effectiveness and effects on the prevention or retardation of associated disease progression. It is desirable for antihypertensives to have a long duration of action so that once-daily dosing is possible. In addition, antihypertensive medication must be able to be administered concomitantly with other drugs likely to be taken by the patients. This is particularly critical in the elderly population. Barnidipine, a novel, long-acting calcium antagonist, has met these challenges of modern pharmacotherapy. Its once-daily dosing, good tolerability and durable antihypertensive effect contribute to excellent patient adherence and make this drug a valuable addition to the antihypertensive formulary.

Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial

“…Where ACE-inhibitors or ARBs are contraindicated or not tolerated, or when they are not enough to reach an adequate blood pressure control, another anti-hypertensive agent should be added, and calcium channel blockers (CCBs) could be an option as second line therapy 10 . At this regard, barnidipine hydrochloride is a 1,4-dihydropyridine CCB with long-lasting vasodilatory effect 11 12 . Its anti-hypertensive action is related to the reduction of peripheral vascular resistance 11 12 .…”

“…At this regard, barnidipine hydrochloride is a 1,4-dihydropyridine CCB with long-lasting vasodilatory effect 11 12 . Its anti-hypertensive action is related to the reduction of peripheral vascular resistance 11 12 . Lercanidipine is a third-generation dihydropyridine CCBs that causes systemic vasodilation by blocking the influx of calcium ions through L-type calcium channels in cell membranes.…”

Effect of Barnidipine on Blood Pressure and Serum Metabolic Parameters in Patients With Essential Hypertension: A Pilot Study

“…Keywords: barnidipine; hypertension; isoprostane; cholesterol; lipoprotein-associated phospholipase A2; plasminogen activator inhibitor 1; paraoxonase; fibrinogen; metabolic parameters B arnidipine hydrochloride is a 1,4-dihydropyridine calcium antagonist with long-lasting vasodilatory effect. 1,2 Its antihypertensive action is related to the reduction of peripheral vascular resistance. 1,2…”

National Survey on Excellence Centers and Reference Centers for Hypertension Diagnosis and Treatment: Geographical Distribution, Medical Facilities and Diagnostic Opportunities

“…With once-daily administration, barnidipine has shown potent antihypertensive action [27]. The modifìed-release, single-isomer formulation of barnidipine provides a slow onset of action combined with a sustained delivery of drug to effectively control BP throughout a 24-h period without causing hypotension or reflex tachycardia [27], and some additional benefits in reducing central blood pressure, possibly explaining the improvement in diastolic function [28]. Finally, its long duration of action, due to its lipophilicity, means that satisfactory BP control can be obtained with once-daily dosing [25].…”