Baroreflex and Cerebral Autoregulation Are Inversely Correlated

Nasr, Nathalie; Czosnyka, Marek; Traon, Anne Pavy-Le; Custaud, Marc‐Antoine; Liu, Xiuyun; Varsos, Georgios V.; Larrue, Vincent

doi:10.1253/circj.cj-14-0445

Cited by 34 publications

(24 citation statements)

References 51 publications

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“…The use of transcranial Doppler necessitates the diameter of the MCA for an appropriate assessment of CBFV. This potential limitation is inherent to all CA studies using transcranial Doppler (Nasr et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation

et al. 2017

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Dry immersion (DI) is used to simulate weightlessness. We investigated in healthy volunteers if DI induces changes in ONSD, as a surrogate marker of intracranial pressure (ICP) and how these changes could affect cerebral autoregulation (CA). Changes in ICP were indirectly measured by changes in optic nerve sheath diameter (ONSD). 12 healthy male volunteers underwent 3 days of DI. ONSD was indirectly assessed by ocular ultrasonography. Cerebral blood flow velocity (CBFV) of the middle cerebral artery was gauged using transcranial Doppler ultrasonography. CA was evaluated by two methods: (1) transfer function analysis was calculated to determine the relationship between mean CBFV and mean arterial blood pressure (ABP) and (2) correlation index Mxa between mean CBFV and mean ABP.ONSD increased significantly during the first day, the third day and the first day of recovery of DI (P < 0.001).DI induced a reduction in Mxa index (P < 0.001) and an elevation in phase shift in low frequency bandwidth (P < 0.05). After DI, Mxa and coherence were strongly correlated with ONSD (P < 0.05) but not before DI. These results indicate that 3 days of DI induces significant changes in ONSD most likely reflecting an increase in ICP. CA was improved but also negatively correlated with ONSD suggesting that a persistent elevation ICP favors poor CA recovery after simulated microgravity.

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Section: Discussionmentioning

confidence: 99%

Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation

et al. 2017

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“…In addition, Nasr et al (2014) found an inverse and strong correlation between baroreflex sensitivity and CA in healthy controls. This suggests that baroreflex modulation of the autonomic drive may play an important role on CA.…”

Section: Determination Of Cerebral Autoregulation: Static and Dynamicmentioning

confidence: 88%

Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation

et al. 2020

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It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning. When astronauts return to Earth, some encounter problems related to orthostatic intolerance. An impaired cerebral autoregulation (CA), which could be compromised by the effects of microgravity, has been proposed as one of the mechanisms responsible for orthostatic intolerance. CA is a homeostatic mechanism that maintains cerebral blood flow for any variations in cerebral perfusion pressure by adapting the vascular tone and cerebral vessel diameter. The groundbased models of microgravity are useful tools for determining the gravitational impact of spaceflight on human body. The head-down tilt bed rest (HDTBR), where the subject remains in supine position at −6 degrees for periods ranging from few days to several weeks is the most commonly used ground-based model of microgravity for cardiovascular deconditioning. head-down bed rest (HDBR) is able to replicate cephalic fluid shift, immobilization, confinement, and inactivity. Dry immersion (DI) model is another approach where the subject remains immersed in thermoneutral water covered with an elastic waterproof fabric separating the subject from the water. Regarding DI, this analog imitates absence of any supporting structure for the body, centralization of body fluids, immobilization and hypokinesia observed during spaceflight. However, little is known about the impact of microgravity on CA. Here, we review the fundamental principles and the different mechanisms involved in CA. We also consider the different approaches in order to assess CA. Finally, we focus on the effects of short-and long-term spaceflight on CA and compare these findings with two specific analogs to microgravity: HDBR and DI.

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“…2). Low baroreceptor sensitivity is commonly seen in patients with hypertension and diabetes, 149,150 carotid atherosclerosis, 151,152 and obesity 153 ; in smokers 154 ; and in patients with high alcohol consumption. 155 Patients with obstructive sleep apnea have an attenuated baroreceptor sensitivity, 156 which is associated with increased blood pressure variability, 157 increased sympathetic activity, 158 desensitization of vascular adrenergic receptors, and decreased peripheral vascular adrenergic responses.…”

Section: Association Of Medical and Health Conditions With Baroreceptmentioning

confidence: 99%

Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes

et al. 2019

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Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain homeostasis by coordinating physiologic responses to external and internal stimuli. While it is recognized that carotid and cardiopulmonary baroreceptor reflexes modulate autonomic output to mitigate excessive fluctuations in arterial blood pressure and to maintain intravascular volume, increasing evidence suggests that baroreflex pathways also project to key regions of the central nervous system that regulate somatosensory, somatomotor, and central nervous system arousal. In addition to maintaining autonomic homeostasis, baroreceptor activity modulates the perception of pain, as well as neuroimmune, neuroendocrine, and cognitive responses to physical and psychologic stressors. This review summarizes the role that baroreceptor pathways play in modulating acute and chronic pain perception. The contribution of baroreceptor function to postoperative outcomes is also presented. Finally, methods that enhance baroreceptor function, which hold promise in improving postoperative and pain management outcomes, are presented.

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Baroreflex and Cerebral Autoregulation Are Inversely Correlated

Cited by 34 publications

References 51 publications

Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation

Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation

Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation

Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes

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