Baroreflex‐mediated sympathetic overactivation induced by mental stress in post‐traumatic stress disorder depends on the type of stressor

Silva, Luiz Eduardo Virgílio; Katayama, Pedro L.

doi:10.1113/jp274859

Cited by 8 publications

(3 citation statements)

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“…Similar findings have shown altered BEI but normal BRS in veterens with post-traumatic stress disorder [38], and in human subjects with chronic renal insufficiency [39]. This suggests that BRS and BEI might be related to distinct neural pathways within the baroreflex [35], or that BEI can detect early baroreflex dysfunction not detected by BRS [37].…”

Section: Postprandial Changes In Baroreflex Functionsupporting

confidence: 64%

“…Previous work has suggested that BRS and BEI are measures that compliment each other [35]. BRS measures the heart rate response for each 1 mm Hg change in blood pressure (sensitivity), while BEI measures how much of the stimuli is transduced through the baroreflex pathways to a reflex response; that is, how often the baroreflex response is active in the face of blood pressure alterations [36].…”

Section: Postprandial Changes In Baroreflex Functionmentioning

confidence: 99%

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Baroreflex function and postprandial hypotension in older adults

2020

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Purpose Postprandial hypotension (PPH) is a common but poorly understood etiology for fainting in older adults. One potential mechanism is age-related baroreflex dysfunction. We examined baroreflex function in older adults with PPH and without PPH (noPPH) during a standardized meal test. Methods 57 adults (age ≥ 65; 24 PPH, 33 noPPH, mean age 77.9 ± 0.9 years, 54% female) were recruited and had meal tests performed. The baroreflex effectiveness index (BEI, %) and baroreflex sensitivity (BRS, ms/mm Hg) were calculated using the sequence method. Results Baseline BEI (22 ± 2 versus 23 ± 2 percent, t = − 0.411, p = 0.682) and BRS (14.1 ± 2.4 versus 13.8 ± 2.5 ms/mm of Hg, t = − 0.084, p = 0.933) were similar in PPH and noPPH subjects. During the meal test PPH subjects showed significantly lower BEI as compared to noPPH subjects (time × PPH, F = 2.791, p = 0.042), while there was no difference in the postprandial change in BRS (time, F = 0.618, p = 0.605). Conclusion Patients with PPH demonstrated an acute postprandial decrease in baroreflex effectiveness during meal testing as compared with normal subjects, suggesting a potential contributing mechanism for this condition.

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Section: Postprandial Changes In Baroreflex Functionsupporting

confidence: 64%

Section: Postprandial Changes In Baroreflex Functionmentioning

confidence: 99%

Baroreflex function and postprandial hypotension in older adults

2020

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“…In contrast to BRS, BEI reflects the percentage of beat-by-beat AP changes that are effectively translated into reflex changes of the heart rate (HR; Di Rienzo et al, 2001). Therefore, the BEI is considered a complementary index to the BRS, providing additional information regarding baroreflex function (Lataro et al, 2017; Silva and Katayama, 2017).…”

Section: Introductionmentioning

confidence: 99%

Revisiting the Sequence Method for Baroreflex Analysis

et al. 2019

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The sequence method is an important approach to assess the baroreflex function, mainly because it is based on the spontaneous fluctuations of beat-by-beat arterial pressure (for example, systolic arterial pressure or SAP) and pulse interval (PI). However, some studies revealed that the baroreflex effectiveness index (BEI), calculated through the sequence method, shows an intriguing oscillatory pattern as function of the delay between SAP and PI. It has been hypothesized that this pattern is related to the respiratory influence on SAP and/or PI variability, limiting the SAP ramps to 3 or 4 beats of length. In this study, this hypothesis was tested by assessing the sequence method using raw (original) and filtered series. Results were contrasted to the well-established transfer function, estimated between SAP and PI. Continuous arterial pressure recordings were obtained from healthy rats (N = 61) and beat-by-beat series of SAP and PI were generated. Low-pass (LP) and high-pass (HP) filtered series of SAP and PI were created by filtering the original series with a cutoff frequency of 0.8 Hz. Original series were analyzed by either the sequence method or cross-spectral analysis (transfer function) at low- (LF) and high- (HF) frequency bands, while filtered series were evaluated only by the sequence method. Baroreflex sensitivity (BRS) and BEI of original series, calculated by sequence method, was highly (85–90%) determined by HP series, with no significant association between original and LP series. A high correlation (>0.7) was found between the BRS estimated from original series (sequence method) and HF band (transfer function), as well as for LP series (sequence method) and LF band (transfer function). These findings confirmed the hypothesis that the sequence method quantifies only the high-frequency components of the baroreflex, neglecting the low-frequency influences, such as the Mayer waves. Therefore, we propose using both the original and LP filtered time series for a broader assessment of the baroreflex function using the sequence method.

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