Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmia. Implications for clinical trials

Heart rate variability in myocardial infarction and heart failure

“…A number of studies on HRV in acute MI patients have been reported since Wolf et al [14] first proposed that there was a relationship between the two [9,27,[34][35][36][37][38][39][40][41][42][43][44]. In the acute phase of MI, a depressed HRV has been observed for two weeks, followed by recovery [38,45].…”

“…In the acute phase of MI, a depressed HRV has been observed for two weeks, followed by recovery [38,45]. In a retrospective analysis of an ATRAMI (Autonomic Tone and Reflex After Myocardial Infarction) study, which enrolled 1248 patients with recent MI [41,42], the two most popular autonomic markers, HRV (SDNN) and baroreflex sensitivity (BRS), were investigated to test their prediction on cardiac mortality during a two-year follow up. Patients with recent MI (b 28 days) have been recorded for BRS, LVEF, and 24-h ECG.…”

Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002–2006

“…A reduced heart rate variability (HRV) as a marker of autonomic dysfunction has been shown to be associated with a poor prognosis of CVD [8][9][10][11][12][13][14][15][16][17][18][19][20][21], and with an increased risk of incident myocardial infarction (MI), cardiovascular mortality, and death from other causes in the general population [22][23][24][25][26][27][28]. In several studies, it has been shown to be related to established risk factors (RF) of CVD [29][30][31][32][33][34][35][36] as well as to psychosocial factors [29,[37][38][39][40][41][42], suggesting that autonomic dysfunction could be a mediator between RF and adverse health outcomes.…”

Association of heart rate recovery after exercise with indices of obesity in healthy, non-obese adults

“…A delayed HRR is therefore considered a measure of autonomic imbalance (Schwartz et al 1992) and may be a reXection of a reduction in vagal tone or an exaggerated sympathetic activation (Imai et al 1994). A decrease in vagal activity is associated with increased risk of death in a wide spectrum of patients (Schwartz et al 1992;La Rovere et al 2001). Similarly a predominance of sympathetic activity and a reduction in parasympathetic cardiac control is found in patients with acute myocardial infarction (Rothschild et al 1988).…”