Baroreflex Sensitivity Predicts Short-Term Outcome of Postural Tachycardia Syndrome in Children

Li, Hongxia; Liao, Ying; Wang, Yuli; Liu, Ping; Sun, Chufan; Chen, Yonghong; Tang, Chaoshu; Jin, Hongfang; Du, Junbao

doi:10.1371/journal.pone.0167525

Cited by 19 publications

(20 citation statements)

References 42 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Muenter Swift et al reported that POTS patients had exaggerated muscle sympathetic nerve activity (MSNA) responses to baroreflex challenges (including vasoactive drug boluses, Valsalva maneuvers and the standing-up test) compared to healthy control subjects (15). Li et al also found that BRS in children with POTS was significantly higher than that in healthy children (18.76 ± 9.96 ms/mmHg vs. 10 ± 5.42 ms/mmHg, P < 0.01) (14). BRS was positively correlated with HR changes in the POTS group ( r = 0.304, P < 0.05), indicating that BRS was related to the severity of POTS.…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have shown that POTS may be related to autonomic nerve dysfunction, hypovolemia, decreased skeletal muscle pump activity and injured vascular endothelium demonstrated by flow-mediated vasodilation (FMD) and midregional pro-adrenomedullin (MR-proADM) (7–13). Autonomic nerve dysfunction plays an important role in the induction of this disease, and the increased baroreflex sensitivity (BRS) is the key factor (14, 15). BRS has been associated with the severity of POTS and could be used as an effective index to predict the short-term outcome of POTS in children (14).…”

Section: Introductionmentioning

confidence: 99%

“…Autonomic nerve dysfunction plays an important role in the induction of this disease, and the increased baroreflex sensitivity (BRS) is the key factor (14, 15). BRS has been associated with the severity of POTS and could be used as an effective index to predict the short-term outcome of POTS in children (14). This finding demonstrated the vital role of increased BRS in the mechanism of POTS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma Homocysteine Level in Children With Postural Tachycardia Syndrome

Li¹,

He²,

Zhang³

et al. 2018

Front. Pediatr.

Self Cite

View full text Add to dashboard Cite

The study was designed to evaluate the changes of plasma homocysteine (Hcy) level in children with postural tachycardia syndrome (POTS) and explore its significance. A total of 65 subjects were recruited in our study, of whom 35 children were in the POTS group and 30 healthy children were in the control group. Plasma Hcy levels were determined in all subjects. The relationship between the plasma Hcy level and the symptom score was analyzed in the 35 POTS patients. The relationship between the plasma Hcy level and the change in heart rate from the supine to upright position (ΔHR) and between the plasma Hcy level and the rate of increase in heart rate from the supine to upright position (ΔHR/sHR × 100%) were analyzed in all subjects. The plasma Hcy levels were significantly higher in the children with POTS than those in the control group (9.78 [7.68, 15.31] μmol/L vs. 7.79 [7.46, 9.63] μmol/L, P < 0.05). The plasma Hcy levels were positively correlated with symptom scores in the POTS patients (n = 35, r = 0.522, P < 0.01). The plasma Hcy levels were also positively correlated with ΔHR (n = 65, r = 0.332, P < 0.01) and ΔHR/sHR × 100% (n = 65, r = 0.341, P < 0.01) in all the subjects. In conclusion, the plasma Hcy levels were elevated in the children with POTS positively correlated with the severity of POTS, suggesting that Hcy might be involved in the pathogenesis of POTS.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma Homocysteine Level in Children With Postural Tachycardia Syndrome

Li¹,

He²,

Zhang³

et al. 2018

Front. Pediatr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The symptoms of PoTS include nausea, headache, palpitations, dizziness, chest discomfort, blurred vision, shortness of breath, and, in severe cases, syncope. The etiology of PoTS remains quite unclear; some authors suggest that this syndrome is mainly induced by an autonomic nerve dysfunction, and in particular by an increased baroreflex sensitivity (BRS), and BRS is correlated with PoTS symptoms [95,96]. Some studies on hypertensive patients have shown a relationship between HHcy levels and increased BRS [97], probably due to the regulation of oxidative stress mediated by Hcy.…”

Section: Hhcy and Cardiovascular Diseasesmentioning

confidence: 99%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

109

View full text Add to dashboard Cite

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case–control experimental designs and the study of interactions between different factors it should be emphasized.

show abstract

“…The reported therapeutic effects in children with NMS have varied. Therefore, some indicators for predicting the therapeutic response have been studied including baroreflex sensitivity,[ 8 ] the heart rate corrected QTd,[ 9 ] the body mass index, plasma CNP[ 10 ] and so on. These studies provide individualizing therapy for syncopal cases and need to be wildly applied in the clinics in the future.…”

Section: A Dvances O Ver the P mentioning

confidence: 99%