Barrett-Neoplasie: Wo liegt eigentlich das Problem?

Abstract

The Barrett mucosa is characterised by metaplastic transformation in the distal oesophagus from squamous epithelium into columnar-lined cells and shows an increased risk for progression into adenocarcinoma. Up to date an international definition of Barrett's oesophagus is still lacking and it is also difficult to separate low-grade dysplasia/intraepithelial neoplasia from high-grade dysplasia/intraepithelial neoplasia. The present review describes the criteria for the histological diagnosis, discusses the possibilities of endoscopic diagnosis and highlights the biomarkers of the Barrett mucosa.

Histopathological Assessment of the Endoscopic Resection Specimen

“…The specimens should not be stretched and immediately fixated in 4% neutral buffered formalin overnight. Overdiagnoses of reactive lesions as low-grade neoplasia can lead to a situation where studies cannot be compared with each other anymore [15] (Table 1). These diagnostic differences are shown by the varying percentage of lowgrade dysplasia diagnoses in consecutive series of patients.…”