Barrett’s esophagus: best practices for treatment and post-treatment surveillance

Mansour, Nabil; El–Serag, Hashem B.; Anandasabapathy, Sharmila

doi:10.21037/acs.2017.03.05

Cited by 8 publications

(6 citation statements)

References 79 publications

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“…The median expression of FFAR1, FFAR2, FFAR3, and FFAR4 was higher in NERD (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) vs. 39 (22-47) for FFAR4 (p < 0.05 when comparing the expression in ERD to NERD and HCs)). The median expression of FFAR3 was higher in ERD patients than in HCs (Figure 2).…”

Section: Patients With Nerd Exhibited Higher Mrna Expression Of Ffars Compared With Hcs and Patients With Erdmentioning

confidence: 90%

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Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease

Fabisiak

Bartoszek

Talar

et al. 2020

JCM

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Background: The negative impact of a high-fat diet on the course of gastroesophageal reflux disease (GERD) has been previously reported. Free fatty acid receptors (FFARs) may be mediators of this phenomenon. The aim of this study was to characterize the role of FFARs in the course of nonerosive (NERD) and erosive (ERD) reflux disease. Methods: Collectively, 73 patients (62 with GERD and 11 healthy controls (HCs)) were recruited to the study. Esophageal biopsies were drawn from the lower third of the esophagus and kept for further experiments. Quantitative, real-time polymerase chain reaction was used to assess the expression of FFAR1, FFAR2, FFAR3, and FFAR4 in biopsies. Histological evaluation of dilated intracellular spaces (DISs) was also performed. Results: FFAR3 exhibited the highest expression, and FFAR4 exhibited the lowest expression in all esophageal samples. Higher relative expression of FFAR1 and FFAR2 and significantly higher expression of FFAR3 (p = 0.04) was noted in patients with GERD compared to respective HCs. Patients with nonerosive GERD (NERD) presented higher expression of all FFARs compared to patients with erosive GERD (ERD) and respective HCs. Interestingly, in patients with ERD, the expression of FFAR3 was lower than in HCs. Significant, weak, positive correlation was found for FFAR3 and FFAR4 expression and DIS scores (r = 0.36, p < 0.05 for FFAR 3, and r = 0.39, p < 0.05 for FFAR4). Conclusions: In this study, we show that FFARs may play a role in GERD pathogenesis, particularly in the NERD type. It may be assumed that FFARs, in particular FFAR3 and FFAR4, may have diagnostic and therapeutic potential in GERD.

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Section: Patients With Nerd Exhibited Higher Mrna Expression Of Ffars Compared With Hcs and Patients With Erdmentioning

confidence: 90%

“…Long-term acidic esophageal injury in the course of GERD may lead to a precancerous state— Barrett’s esophagus (BE) and/or further gastroesophageal junction adenomatous cancer [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease

Fabisiak

Bartoszek

Talar

et al. 2020

JCM

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“…15 Table 3 summarizes advanced endoscopy techniques and their clinical application and performance characteristics. [16][17][18] Multiple classification systems exist, using vascular and surface patterns, for the prediction of histopathology based on endoscopic narrow band imaging focused. [19][20][21] For instance, the Amsterdam classification is focused on regular versus irregular vascular and mucosa patterns and normal versus abnormal vessels and it has good diagnostic value with a sensitivity of 94%, a specificity of 76%, a positive predictive value (PPV) of 64%, and a negative predictive value (NPV) of 98% for high grade intraepithelial neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Taking the Next Steps in Endoscopic Visual Assessment of Barrett’s Esophagus: A Pilot Study

Chis¹,

Hew²,

Hopman³

et al. 2021

CEG

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Purpose: Patients with Barrett's esophagus (BE) undergo surveillance endoscopies to assess for pre-cancerous changes. We developed a simple endoscopic classification method for predicting non-dysplastic BE (NDBE), low-grade dysplasia (LGD)/indefinite for dysplasia (ID) and high-grade dysplasia (HGD)/early esophageal adenocarcinoma (EAC). Patients and Methods: Twenty-two patients with BE underwent endoscopy using the PENTAX Medical MagniView gastroscope and OPTIVISTA processor. Sixty-six video-still images were analyzed to characterize the microsurface, microvasculature and the presence of a demarcation line. Class A was characterized by regular microvascular and microsurface patterns and absence of a demarcation line, class B by changes in the microvascular and/or microsurface patterns compared to the background mucosa with presence of a demarcation line, and class C by irregular microvascular and/or irregular microsurface patterns with presence of a demarcation line. Results: Of the class A images, 97.9% were NDBE. For class B, 69.2% were LGD/ID and 30.8% NDBE. One hundred percent of the class C samples were HGD/EAC. The sensitivity of our classification system was 93.8%, specificity 92%, positive predictive value 78.9%, negative predictive value 97.9% and an accuracy 92.4%. Conclusion:In this study, we developed a simple classification system for the prediction of NDBE, LGD/ID and HGD/EAC. Its real-time clinical applicability will be validated prospectively.

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“…However, there is high interobserver variability owing to a lack of classification, unequal distribution of dye over the mucosa, and increased procedure time making this technique uncommon. 65 , 67 , 68 …”

Section: Surveillancementioning

confidence: 99%

“…The clinical significance of subsquamous BE is not known but likely carries a low risk of progression as subsquamous EAC is infrequent. 67 …”

Section: Surveillancementioning

confidence: 99%

Barrett’s esophagus: novel strategies for screening and surveillance

Sanghi

Thota

2019

Therapeutic Advances in Chronic Disease

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Barrett’s esophagus is the precursor lesion for esophageal adenocarcinoma. Screening and surveillance of Barrett’s esophagus are undertaken with the goal of earlier detection and lowering the mortality from esophageal adenocarcinoma. The widely used technique is standard esophagogastroduodenoscopy with biopsies per the Seattle protocol for screening and surveillance of Barrett’s esophagus. Surveillance intervals vary depending on the degree of dysplasia with endoscopic eradication therapy confined to patients with Barrett’s esophagus and confirmed dysplasia. In this review, we present various novel techniques for screening of Barrett’s esophagus such as unsedated transnasal endoscopy, cytosponge with trefoil factor-3, balloon cytology, esophageal capsule endoscopy, liquid biopsy, electronic nose, and oral microbiome. In addition, advanced imaging techniques such as narrow band imaging, dye-based chromoendoscopy, confocal laser endomicroscopy, volumetric laser endomicroscopy, and wide-area transepithelial sampling with computer-assisted three-dimensional analysis developed for better detection of dysplasia are also reviewed.

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Barrett’s esophagus: best practices for treatment and post-treatment surveillance

Cited by 8 publications

References 79 publications

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease

Taking the Next Steps in Endoscopic Visual Assessment of Barrett’s Esophagus: A Pilot Study

Barrett’s esophagus: novel strategies for screening and surveillance

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