2022
DOI: 10.4103/2221-1691.335697
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Barrientosiimonas humi ethyl acetate extract exerts cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest

Abstract: Objective: To elucidate the cytotoxic effect of the secondary metabolites of Barrientosiimonas humi (B. humi) on MCF-7 and MDA-MB-231 human breast cancer cells and its underlying mechanisms of action. Methods: The extract was obtained from the fermentation of B. humi and fractionation of the crude extract was conducted via column chromatography. Cytotoxicity of the B. humi extract was determined by using MTT assay and real-time cellular analysis. Morpho… Show more

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“…Following the manufacturer's instructions, cells were fixed and analysis steps were carried out. Muse Cell Analyzer was used to measure the cell population at various cell cycle stages (G1, S, G2, and M) (Millipore) [19].…”
Section: Cell Cycle Analysismentioning
confidence: 99%
“…Following the manufacturer's instructions, cells were fixed and analysis steps were carried out. Muse Cell Analyzer was used to measure the cell population at various cell cycle stages (G1, S, G2, and M) (Millipore) [19].…”
Section: Cell Cycle Analysismentioning
confidence: 99%