Barrier Gesture Relaxation during Vaccination Campaign in France: Modelling Impact of Waning Immunity

Abstract

Non-pharmaceutical interventions have been implemented intermittently for more than a year in most countries of the world to mitigate the COVID-19 epidemic. In France, while the vaccination campaign is progressing, the French government has decided to remove many public health restrictions such as business closure, lockdowns, and curfews. Nonetheless, social distancing, mask wearing, and hand washing (also called barrier gestures) are still recommended. We utilize an age-structured compartmental SEIR model that takes into account the SARS-CoV-2 waning immunity, vaccination, and increased transmissibility from variants of concern to estimate if barrier gestures can be relaxed without causing a resurgence of severe infections. This model assumes that the susceptibility to infection is a function of immunity status, which depends on initial infection severity and vaccination status. It is calibrated on confirmed COVID-19 cases from the French surveillance database, and accounts for changes in contact behaviors due to the implementation of nation-wide public health policies. We study the partial and full relaxation of barrier gestures occurring from August to December 2021 under various immunity duration assumptions. Maintaining the application of barrier gestures appears essential to avoid a resurgence of severe infections that would exceed French health care capacities, while surmounting vaccine hesitancy represents the key to consider their relaxation. Immunity duration assumptions significantly influence the short-term dynamic of the epidemic, which should be considered for further modelling.

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“…Manual collection and continuous validation of data ensure the high quality of CPRCT database. Our database may serve as a valuable resource for the Canadian modelling and research community as well as other researchers elucidating the impacts of public health mitigation on the Covid-19 pandemic 5 , 6 . Categorization of public health interventions into three groups can be beneficial for mathematical modelling activities and projects because it eliminates the problem of redundancy and overfitting.…”

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“…These epidemic models can also be coupled with models describing behaviors that are affected by and affect the disease transmission dynamics [18,19]. Some the proposed COVID-19 compartmental models have considered how individuals respond to the disease dynamics and how the disease dynamics are affected by these behavioural responses [20][21][22][23][24][25][26][27][28][29][30].…”