A novel three-dimensional integrated guidance and control (3D-IGC) approach is developed for sliding-to-turn (STT) missile, which achieves an asymptotic tracking performance with various disturbances. First, a nonlinear state-space model is established to design the 3D-IGC law. Then, a control approach based on the improved robust integral of the sign of error (RISE) is proposed to guarantee both the angle and angular rates of the look of sight (LOS) to be tightly tracked. In addition, a novel error transformation is introduced so as to transmit the mismatched modeling uncertainties to control input channel. Then, the improved RISE can handle both mismatched and matched modeling uncertainties together in the design of the controller. The closed-loop system stability and the convergence characteristic are rigorously proved via Lyapunov theory. Finally, the extensive contrast simulations are implemented to demonstrate the effectiveness and robustness of the proposed control strategy. INDEX TERMS Integrated guidance and control, RISE, modeling uncertainty, asymptotic tracking.