“…Implementation of model‐informed and optimal design approaches can further contribute to overcome “classical” TDM problems, such as inappropriate timing, quality, and quantity of PK or biomarker samples. Often highlighted major concerns in traditional TDM still comprise long bioanalytical turnaround times of samples (several hours to weeks), lack of standardization in workflows, and high instrumentation costs with complex sample preparation 8 . Raising awareness for benefits of optimal (often earlier and less) sampling timepoints, streamlining internal processes to shorten turnaround times, and introducing new concepts (e.g., point‐of‐care/bedside analytics, biosensors/wearables, and home‐monitoring systems 9 ), using not only plasma, but also, for example, saliva, interstitial fluid, or capillary blood, will offer practical solutions to the challenges listed above.…”