The article discusses the practice of shaping global health as a focused institutional response of the international community to the challenges of a changing world and the most important factor in ensuring security. Growing global factors continue to make health security an integral part of international policy through the collaboration of the World Health Organization (WHO) and other actors. The state of health security, changing values, and rising expectations determine the adoption of new systemic decisions by WHO and other global health actors, leading to the revision of traditional approaches in order to respond effectively to current challenges.