Barriers in the treatment of latent tuberculosis infection (LTBI) in children: a case study

Silva, Adriana Rodrigues da; Sousa, Ana Inês; ́Anna, Clemax Couto Sant

doi:10.5935/1414-8145.20140055

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the natural history of TB, 5% of infected individuals will develop active disease during the first years after infection and another 5% may remain latently infected and may develop active TB at some point later in life 3 . Therefore, disease control in individuals recently exposed to a TB index case (IC) is an important strategy to help TB control and prevent the onset of LTBI, especially among household and immunosuppressed contacts 4 , 5 ; however, according to the WHO 4 , fewer than 50% of cases are assessed and treated preventively.…”

Section: Introductionmentioning

confidence: 99%

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon

Cardoso

Fonseca

Neto

et al. 2017

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

We carried out a cross-sectional study from January to December 2015 on 1,425 inhabitants from a floating population in the Brazilian Amazon (Murinin district, Pará State) to describe the population-based prevalence of tuberculosis (TB) from 2011 to 2014, recent TB contacts (rCts) latently infected with Mycobacterium tuberculosis (LTBI) , the coverage of the local health network, socio-environmental factors, and frequency of intestinal parasitic infection (IPI). We found that the sanitary structure was inadequate, with latrines being shared with other rooms within the same accommodation; well water was the main source of water, and 48% of families had low incomes. The average rate of TB was 105/100, 000 inhabitants per year; one third of TB patients had been household contacts of infected individuals in the past, and 23% of rCts were LTBI. More than half (65%) of 44% of the stools examined (representing 76% of the housing) had IPIs; the highest prevalence was of fecal-oral transmitted protozoa (40%, Giardia intestinalis ), followed by soil-transmitted helminths (23%). TB transmission may be related to insufficient disease control of rCts, frequent relocation, and underreporting. Education, adopting hygienic habits, improving sanitation, provision of a treated water supply and efficient sewage system, further comprehensive epidemiological surveillance of those who enter and leave the community and resources for basic treatment of IPIs are crucial in combating the transmission of these neglected diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon

Cardoso

Fonseca

Neto

et al. 2017

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil

et al. 2016

View full text Add to dashboard Cite

BackgroundRoutine data on the use of isoniazid preventive therapy (IPT) in children and adolescents are scarce in high tuberculosis (TB) burden countries.ObjectiveTo describe the factors related to abandonment of IPT in children and adolescents with latent tuberculosis infection (LTBI) receiving routine care.MethodsRetrospective (2005–2009) descriptive study of 286 LTBI cases with indication of IPT and serviced at a pediatric hospital in the State of Rio de Janeiro, Brazil. Survival analysis of the risk of abandonment of IPT over six months was performed, including multivariate analysis using the Cox proportional hazards model.ResultsOut of the 245 cases of LTBI included, 62 abandoned IPT (25.3%; 95% CI: 20%-31%). On multivariate analysis, the variables related to the IPT abandonment hazard ratio were the Human Development Index (HDI) (hazard ratio—HR: 0.004; 0.000–0.569) of the place of residence and the contact with adults that were not undergoing anti-TB treatment (HR: 7.30; 1.00–53.3).ConclusionThis study reveals the relevance of the relation of abandonment of IPT to the socioeconomic conditions at the place of residence and poor adherence to the active TB treatment. Educational measures to stimulate preventive treatment of child contacts and curative treatment of index cases should target the full familial setting.

show abstract

Barriers in the treatment of latent tuberculosis infection (LTBI) in children: a case study

Cited by 2 publications

References 4 publications

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon

Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil

Contact Info

Product

Resources

About