Barriers in the Tumor Microenvironment to Nanoparticle Activity

Abumanhal-Masarweh, Hanan; Koren, Lilach; Adir, Omer; Kaduri, Maya; Poley, Maria; Chen, Gal; Avital, Aviram; Pauker, Noga Sharf; Mumblat, Yelena; Shklover, Jeny; Shainsky‐Roitman, Janna; Schroeder, Avi

doi:10.1201/9781003125259-15

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“…Macromolecular drugs or particles with diameters of 100 nm are more likely to accumulate in tumor tissue because of this difference; additionally, specific pH, enzyme environment, and reduction environment in tumor site can be used to achieve the release of drugs at specific sites in order to achieve the goal of targeted drug delivery ( 29 ). Tumor cells proliferate rapidly, resulting in a lack of blood vessels and lymphatics in the tumor tissue, which results in a high rate of leakage of substances from blood vessels into the tumor tissue, which can’t easily return to the lymphatic vessels, increasing the retention and infiltration of the tumor ( 30 ). To distribute macromolecules or nanoparticles by tumor extravasation, the retention effect of solid tumours is unique.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in nanomedicine preparative methods and their therapeutic potential for colorectal cancer: a critical review

Jain

Bhattacharya

2023

Front. Oncol.

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Colorectal cancer (CRC) is a prevalent malignancy that affects a large percentage of the global population. The conventional treatments for CRC have a number of limitations. Nanoparticles have emerged as a promising cancer treatment method due to their ability to directly target cancer cells and regulate drug release, thereby enhancing therapeutic efficacy and minimizing side effects. This compilation examines the use of nanoparticles as drug delivery systems for CRC treatment. Different nanomaterials can be used to administer anticancer drugs, including polymeric nanoparticles, gold nanoparticles, liposomes, and solid lipid nanoparticles. In addition, we discuss recent developments in nanoparticle preparation techniques, such as solvent evaporation, salting-out, ion gelation, and nanoprecipitation. These methods have demonstrated high efficacy in penetrating epithelial cells, a prerequisite for effective drug delivery. This article focuses on the various targeting mechanisms utilized by CRC-targeted nanoparticles and their recent advancements in this field. In addition, the review offers descriptive information regarding numerous nano-preparative procedures for colorectal cancer treatments. We also discuss the outlook for innovative therapeutic techniques in the management of CRC, including the potential application of nanoparticles for targeted drug delivery. The review concludes with a discussion of current nanotechnology patents and clinical studies used to target and diagnose CRC. The results of this investigation suggest that nanoparticles have great potential as a method of drug delivery for the treatment of colorectal cancer.

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Section: Introductionmentioning

confidence: 99%