Background: Adolescence is a stage of rapid transition of physical, psychological and emotional development. Parent-adolescent communication has great role on the reduction of SRH problem of adolescents. However evidences shows that there is a silence between parent and adolescent because of this adolescent are affected by STIs, HIV, unsafe abortion and unwanted pregnancy. Therefore this study tried to identify factors that hinder communication in Wogdie district North East Ethiopia.Method: A community based cross-sectional study supplemented with qualitative data was conducted. Six hundred fifteen mothers were selected by multi-stage sampling method for quantitative study. Interviewer administered questionnaire was used for quantitative data collection. Multiple binary logistic regression analysis was executed to assess the association between variables. Participants were selected by purposive sampling method for qualitative part. Fourteen participants were participated in in-depth interview. The qualitative data was transcribed manually using verbatim approach.Results: The magnitude of parent-adolescent communication was 198 (32.8%) with 95% CI (29.1, 36.7). Rural residence of mother [AOR=0.056, 95% CI (0.01, 0.331)], family size of >6 [AOR=0.338, 95% CI (0.13, 0.874)], maternal education status of uneducated [AOR=0.421, 95% CI (0.186, 0.951)], maternal occupational status of housewife [AOR=0.085, 95% CI (0.024, 0.298)], low wealth status [AOR=0.316, 95% CI (0.129, 0.777)], poor maternal knowledge about SRH [AOR=0.063, 95% CI (0.024, 0.164)] and negative maternal attitude towards SRH communication [AOR=0.037, 95% CI (0.008, 0.169)] were have significant negative association with parent-adolescent communication. Cultural taboo, fear and lack of knowledge were reasons that hinder communication.Conclusion: Communication on sexual and reproductive health issue between parent and adolescent was low. Home to home and community health education of mothers is important to create good knowledge and positive attitude about sexual and reproductive communication.