The Charles University in Prague, Czech Republic was selected as one of World Centres of Excellence on Landslide Risk Reduction for the period of 2008-2011. It focused mainly on field research and capacity building, is based on multilateral cooperation both at the national and international levels. Landslides are studied in a holistic context of the whole landscape evolution to understand the complex network of interactions between all of the relevant geomorphologic processes. The field research is carried on field mapping, direct monitoring and data analyses in several parts of Central Europe, Central Asia, selected parts of the Andes and East Africa. We are productively implementing complex system theory (e.g. plectics, non-linear dynamics, networks theory) in more relevant description, modelling and forecasting of landslide processes. Geomorphology is also a useful tool in recognition and description of large prehistoric slope movements.