Barriers to Low-Dose CT Lung Cancer Screening among Middle-Aged Chinese

Abstract

Purpose: The current study aims to explore the barriers for middle-aged Chinese to learn about and uptake low-dose computed tomography (LDCT) lung cancer screening. Methods: Data were collected via an online survey in December 2019. Final valid sample included 640 respondents, aged 40–60 years old, from 21 provinces of China. We performed multiple linear regressions to test the potential barriers to LDCT scan. Findings: Cost concerns, distrust in doctors, fears of disease, lack of knowledge, and optimistic bias are negatively associated with the intention to learn about and uptake LDCT scan. Implications: Our study contributes to understanding the negative predictors of middle-aged Chinese to get LDCT lung cancer scans. Future campaign programs should help audiences to build comprehensive understandings about lung cancer and LDCT scan. To better promote LDCT scan in China, the government should fund more trial programs continuously and public efforts should be made to rebuild the patient–doctor trust.

A Highly Sensitive and Specific Non‐Invasive Test through Genome‐Wide 5‐Hydroxymethylation Mapping for Early Detection of Lung Cancer

“…One promising alternative is blood-based biomarker tests, which are intrinsically minimally invasive and convenient in the clinic. [43] CY211, CEA, NSE, and progastrin-releasing peptide are examples of lung cancer biomarkers in blood. [6,7] However, these biomarkers do not have the level of sufficient sensitivity or specificity to be used as standalone screening tests.…”

“…Moreover, the fact that our cfDNA‐based wd‐score detected patients that showed positive pulmonary nodules demonstrated its potential to be used as a clinically convenient alternative diagnostic tool for patients with limited access to LDCT, particularly for patients from rural areas of China or other countries where fewer healthcare providers are located. [ 44,45 ] It is also worth noting that even though the current clinical study did not aim to explore molecular mechanisms, most of the genes in the final model for lung cancer were found to be linked with gene dysregulation in TCGA lung cancer tumors, suggesting their relevance to the biology of NSCLC. Furthermore, despite not being directly trained using SCLC, the 5hmC‐based diagnostic model was able to identify these patients with a comparable level of sensitivity and specificity.…”

Reduction in Irradiation Dose in Aperture Coded Enhanced Computed Tomography Imager Using Super-Resolution Techniques

“…In this paper, we would like to expend the use of multi pinholes techniques to more medical modalities such as Computerized Tomography (CT). In the CT procedure, there is a need for a novel configuration and operation technique to enable three-dimensional imaging of a body with decreased radiation level and preferably increasing resolution compared to current conventional CT techniques [ 9 , 10 , 11 ].…”