This study aimed to examine the effects of an exposure-based resistance training (RT) intervention on perceived barriers, benefits, and motives for RT in college-aged females and to assess moderating effects of a trainer-trainee relationship on any intervention outcomes. A sample of 13 (Mage = 20.7 ± 1.3y) physically active, non-resistance training female students completed an 8-week intervention (1hr 45min, twice per week). The intervention was effective in reducing perceived time/effort (t[12] = 5.02, p < 0.001, d = 1.81), physical effect (t[12] = 2.48, p = 0.029, d = 0.86) and social (t[12] = 4.86, p < .001, d = 1.97) RT barriers. A positive change pattern was established in stress management (t[12] = 2.21, p = 0.048, d = 0.62), revitalization (t[12] = 2.71, p = .019, d = 0.95), and enjoyment (t[12] = 3.53, p = .004, d = 1.18). Finally, the analyses showed that goal (β = 0.23[0.02], p < 0001, R2 = 0.979) and bond (β = 0.21[.01], p < 0001, R2 = 0.995) alliances were positive moderators with large-sized effects on changes in physical barriers. For stress management, bond alliance was the only statistically significant, small-sized moderator, with a greater bond increasing the effect on the intervention (β = 0.21[.01], p < 0001, R2 = 0.997). This data suggests that an exposure-based RT intervention is beneficial for reducing perceived RT barriers in physically active, non-resistance training college-aged women and that bond-oriented support from the trainer is especially impactful in reducing some of those perceived barriers.