“…1,20,21 Although DA efforts have been protocolized at many institutions, survey and observational data suggest that DA use is low. [22][23][24][25][26] This may be a result of existing ICU clinician perception surrounding DA use (ie, it compromises patient comfort, increases the incidence of patient-initiated device removal, leads to respiratory compromise, and/or is difficult to coordinate among clinicians) and the challenges of replicating an intervention that has been evaluated in a tightly controlled clinical trial in routine ICU clinical practice. [25][26][27]28 While rigorous, controlled studies demonstrate a DA-SBT strategy is both safe and effective when DA-SBT compliance is very high, the impact of a DA-SBT protocol on patient outcomes in the uncontrolled clinical setting, where compliance may be low, remains unclear.…”