Barringtonia acutangula improves the biochemical parameters in diabetic rats

Marslin, Gregory; Khandelwal, Vinoth Kumar Megraj; Mary, Revina Ann; Kalaichelvan, V. K.; Venkatesan, G. K. D. Prasanna

doi:10.1016/s1875-5364(14)60020-0

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Majority of Barringtonia species are native in the tropical and subtropical regions growing in Africa, southern Asia (Malaysia, Indonesia, and Philippines), Australia, and various islands of the Pacific and Indian Oceans. More than 60 species have been identified under this genus with nutritional and medicinal values [20]; however, B. racemose [21][22][23][24], B. asiatica [24][25][26], and B. acutangular [27][28][29][30][31] are the most well-studied species. In the Philippines, B. asiatica is known as a folkloric medicine [24][25][26] that can cure several ailments.…”

Section: There Are Also Medicinal and Herbal Plants Known To Have Potential Activities Against Ovarianmentioning

confidence: 99%

Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells

Villanueva

Vicera

Leonida

et al. 2021

JPRI

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Barringtonia asiatica, is traditionally used as a medicinal plant in the Philippines; unfortunately, there is limited evidence supporting its anticancer capability. Thus, our study investigated the cytotoxic effect of B. asiatica seed extract against ovarian carcinoma A2780 (ECACC 93112519) and Saccharomyces cerevisiae as a cancer model organism. Seeds of B. asiatica were freeze-dried and extracted with methanol. The seed extract was investigated for its effect on the cell cycle in S. cerevisiae by utilizing yeast budding experiment and imaging flow cytometry. Its cytotoxicity activity was also tested as well as a live/dead assay was conducted against ovarian cancer cells. Findings revealed the anticancer activity of B. asiatica and its capability to induce G1 cell cycle arrest in S. cerevisiae. Thus, B. asiatica seeds may serve as a potential source of natural compounds towards anticancer drug discovery.

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Section: There Are Also Medicinal and Herbal Plants Known To Have Potential Activities Against Ovarianmentioning

confidence: 99%

Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells

Villanueva

Vicera

Leonida

et al. 2021

JPRI

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“…B. acutangula plant is traditionally used for the treatment and cure of various ailments like liver disorders, splenic disorders, stomach disorders as well as leprosy. [11][12][13] Various researchers already have mentioned its antioxidant properties, which can be useful in cytoprotection and tissue recovery. Cytoprotection and tissue recovery is the prime motto in wound healing.…”

Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of Topical Herbal Gels Containing Barringtonia acutangula Fruit Extract: In silico and In vivo Studies

Priyanka,

Sahoo,

Nanda

et al. 2024

Chemistry & Biodiversity

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The current study describes the efficacy of B. acutangula fruit extract in wound healing via incorporation within topical gels. B. acutangula fruit extract was produced by solvent extraction method. The bioactive extract was incorporated within Carbopol 940‐based topical gels, which were applied topically over the excision and incision wounds. The change in healing process was observed till 20 days. The percentages of closure of excision wound area were 92.89% and 93.43%, when treated with topical herbal gels containing B. acutangula fruit extract of 5% and 10%, respectively. The tensile strengths of incision area in rats treated with topical herbal gels containing 5% and 10% methanol extract of B. acutangula fruits were found to be 25 ± 5.12 g and 30 ± 4.10 g, respectively. The wound healing activity of topical herbal gels containing B. acutangula fruit extract in rats was found to be significant when compared with that of the reference standard and untreated groups. In addition, in silico studies suggested about good skin permeability and binding to the proteins responsible for delaying wound healing. It can be concluded that this topical herbal gels containing B. acutangula fruit extract could be used clinically for the treatment of wounds.

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“…Traditionally, parts of B. acutangula, like root, seed, bark, and leaf, are used as carminative, expectorant, bitter tonic, emetic, and also in treating diarrhea and gonorrhea. Seeds and leaves are useful in treating colic, intestinal worms, wounds, ulcers, skin diseases, and hallucinations; the bark is an astringent in diarrhea and a febrifuge in malaria [6][7][8][9][10][11][12] . Natural antioxidants present in plants scavenge harmful free radicals from our bodies.…”

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confidence: 99%

Untitled

2023

IJPSR

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Barringtonia acutangula (L.) Gaertn.(Family: Lecythidaceae), is a medium-sized tree found throughout India. It has been used in folk medicine to treat tuberculosis, skin disease, inflammation, hemorrhoids and diarrhea. The present study deals with in-vitro antioxidant, antimicrobial and GC-MS study on the bark extract of B. acutangula. In order to investigate the antioxidant activity, reducing power activity was used. Antibacterial activity was evaluated by disc diffusion method. Identification of extract bioactive compounds by GC-MS revealed that alpha-Pinene oxide, 1,2-benzoldicarbonsaeure di-(hex-1en-5-yl-ester), 3-methyl-4-heptanone, (Z)-3-hexadecene are the major components. The antioxidant activity of the bark extract increased with increasing concentration; the values are comparable with the standard antioxidant ascorbic acid. From the results of antibacterial activity, B. acutangula bark extract could inhibit gram-negative and gram-positive pathogenic bacteria. Thus, B. acutangula could be considered as an excellent broad-spectrum antibacterial agent. INTRODUCTION:Herbal plants play a key role in the treatment of complex diseases in humans due to their complex mixture of secondary metabolites 1 . Barringtonia acutangula Linn. is a medium size glabrous tree found throughout India in deciduous and evergreen forests, mostly along the bank of rivers and streams 2 . B. acutangula is one of the useful traditional medicinal plant in India. It is used in various Ayurvedic formulations for the treatment of various diseases 3 . B. acutangula is used in managing diabetes, obesity, hypertension, and cardiovascular diseases and in various polyherbal formulations 4, 5 .

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Barringtonia acutangula improves the biochemical parameters in diabetic rats

Cited by 4 publications

References 15 publications

Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells

Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells

Wound Healing Activity of Topical Herbal Gels Containing Barringtonia acutangula Fruit Extract: In silico and In vivo Studies

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