Bartonella DNA in heart tissues of bats in central and eastern Europe and a review of phylogenetic relations of bat-associated bartonellae

Corduneanu, Alexandra; Sándor, Attila D.; Ionică, Angela Monica; Hornok, Sándor; Leitner, Natascha; Bagó, Zoltán; Stefke, Katharina; Fuehrer, Hans‐Peter; Mihalca, Andrei Daniel

doi:10.1186/s13071-018-3070-7

Cited by 28 publications

(24 citation statements)

References 55 publications

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“…For 11 of the Bartonella OTUs in this study, community assignments corresponded well with other sequence data collected from related bats in Africa, Asia, and Europe (Kosoy et al, 2010a;Lin et al, 2012;Morse et al, 2012;Anh et al, 2015;Wilkinson et al, 2016;Han et al, 2017;Lilley et al, 2017;Stuckey et al, 2017a;Corduneanu et al, 2018). Further details on comparisons between OTUs and other sequences from previous studies can be found in the Supplementary Material.…”

Section: Network Analysis and Community Assignmentsupporting

confidence: 80%

“…Using these Bartonella OTUs, we can understand their ecology, specifically their host and ectoparasite associations, factors that can aid in demarcating Bartonella species or species complexes (Kosoy, 2010;Kosoy et al, 2012). Additional post hoc comparisons of OTUs with recently published Bartonella sequences from insectivorous bats in China and western, central, and eastern Europe were performed (Han et al, 2017;Stuckey et al, 2017a;Corduneanu et al, 2018). Phylogenetic diversity (PD) of Bartonella sequences from each bat species was assessed by the number of OTUs found in the species and (Faith, 1992) PD index based on branch lengths in 100 posterior samples of the gltA tree.…”

Section: Phylogenetic Analysis Of Bartonella Sequencesmentioning

confidence: 99%

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Host Phylogeny, Geographic Overlap, and Roost Sharing Shape Parasite Communities in European Bats

et al. 2019

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How multitrophic relationships between wildlife communities and their ectoparasitic vectors interact to shape the diversity of vector-borne microorganisms is poorly understood. Nested levels of dependence among microbes, vectors, and vertebrate hosts may have complicated effects on both microbial community assembly and evolution. We examined Bartonella sequences from European bats and their ectoparasites with a combination of network analysis, Bayesian phylogenetics, tipassociation and cophylogeny tests, and linear regression to understand the ecological and evolutionary processes that shape parasite communities. We detected seven batectoparasite-Bartonella communities that can be differentiated based on bat families and roosting patterns. Tips of the Bartonella tree were significantly clustered by host taxonomy and geography. We also found significant evidence of evolutionary congruence between bat host and Bartonella phylogenies, indicating that bacterial species have evolved to infect related bat species. Exploring these ecological and evolutionary associations further, we found that sharing of Bartonella species among bat hosts was strongly associated with host phylogenetic distance and roost sharing and less strongly with geographic range overlap. Ectoparasite sharing between hosts was strongly predicted by host phylogenetic distance, roost sharing, and geographic overlap but had no additive effect on Bartonella sharing. Finally, historical Bartonella host-switching was more frequent for closely related bats after accounting for sampling bias among bat species. This study helps to disentangle the complex ecology and evolution of Bartonella bacteria in bat species and their arthropod vectors. Our work provides insight into the important mechanisms that partition parasite communities among hosts, particularly the effect of host phylogeny and roost sharing, and could help to elucidate the evolutionary patterns of other diverse vector-borne microorganisms.

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Section: Network Analysis and Community Assignmentsupporting

confidence: 80%

Section: Phylogenetic Analysis Of Bartonella Sequencesmentioning

confidence: 99%

Host Phylogeny, Geographic Overlap, and Roost Sharing Shape Parasite Communities in European Bats

et al. 2019

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“…The diversity of Bartonella found in bats in recent studies reveals the importance of this mammal group as hosts of the different Bartonella genotypes ( Bai et al, 2012 ; Corduneanu et al, 2018 ; do Amaral et al, 2018 ; Ferreira et al, 2018 ; Ikeda et al, 2017 ; McKee et al, 2016 ; Stuckey et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Bartonella spp. in brazilian mammals with emphasis on rodents and bats from the Atlantic Forest

Gonçalves-Oliveira

Rozental

Guterres

et al. 2020

International Journal for Parasitology: Parasites and Wildlife

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The Bartonella species are zoonotic agents that infect mammals and are transmitted by arthropod vectors. Approximately 18 distinct genotypes cause diseases in humans, and may be spread by both domestic and wild animals. In Brazil, Bartonella genotypes have been identified in several species of wild mammals, and in the present study, we analyzed samples from non-human primates (marmosets), marsupials, rodents, and bats, and compared them with the genotypes described in mammals from Brazil, to examine the distribution of Bartonella genotypes in two impacted areas of Rio de Janeiro state, in southeastern Brazil. We used polymerase chain reaction (PCR) methods to detect the Bartonella DNA using partial sequences of the gltA, ftsZ , and groEL genes. We generated Bayesian inference and maximum likelihood trees to characterize the positive PCR samples and infer the phylogenetic relationships of the genotypes. A total of 276 animals were captured, including 110 bats, 91 rodents, 38 marsupials, and 37 marmosets. The DNA of Bartonella was amplified from tissue samples collected from 12 (4.34%) of the animals, including eight rodents – Akodon cursor (5/44) and Nectomys squamipes (3/27) – and four bats, Artibeus lituratus (3/58) and Carollia perspicillata (1/15). We identified Bartonella genotypes closely related to those described in previous studies, as well as new genotypes in both the rodent and the bat samples. Considering the high diversity of the Bartonella genotypes and hosts identified in the present study, further research is needed to better understand the relationships between the different Bartonella genotypes and their vectors and host species. The presence of Bartonella in the wild rodents and bats from the study area indicates that the local human populations may be at risk of infection by Bartonella due to the spillover of these strains from the wild environment to domestic and peri-domestic environments.

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“…All major groups of microparasites have been reported widely, though our knowledge of the diversity and distribution of many groups remains scarce. Bacteria such as Bartonella show a high molecular and geographic diversity in bats and bat flies, at global and regional scales (44, 46, 118). Six major bat associated Bartonella clades have been reported so far from bats and bat flies (118).…”

Section: Discussionmentioning

confidence: 99%

“…Bacteria such as Bartonella show a high molecular and geographic diversity in bats and bat flies, at global and regional scales (44, 46, 118). Six major bat associated Bartonella clades have been reported so far from bats and bat flies (118). Clade I, II, IV, and V are represented in both Old and New World areas while clade III seems to be restricted to the Old World (Africa, Asia, and Europe) and clade VI to some parts of the New World (Central America) (118).…”

Section: Discussionmentioning

confidence: 99%

Bat Flies and Their Microparasites: Current Knowledge and Distribution

2019

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Bats are the second most diverse mammalian group, playing keystone roles in ecosystems but also act as reservoir hosts for numerous pathogens. Due to their colonial habits which implies close contacts between individuals, bats are often parasitized by multiple species of micro- and macroparasites. The particular ecology, behavior, and environment of bat species may shape patterns of intra- and interspecific pathogen transmission, as well as the presence of specific vectorial organisms. This review synthetizes information on a multi-level parasitic system: bats, bat flies and their microparasites. Bat flies (Diptera: Nycteribiidae and Streblidae) are obligate, hematophagous ectoparasites of bats consisting of ~500 described species. Diverse parasitic organisms have been detected in bat flies including bacteria, blood parasites, fungi, and viruses, which suggest their vectorial potential. We discuss the ecological epidemiology of microparasites, their potential physiological effects on both bats and bat flies, and potential research perspectives in the domain of bat pathogens. For simplicity, we use the term microparasite throughout this review, yet it remains unclear whether some bacteria are parasites or symbionts of their bat fly hosts.

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Bartonella DNA in heart tissues of bats in central and eastern Europe and a review of phylogenetic relations of bat-associated bartonellae

Cited by 28 publications

References 55 publications

Host Phylogeny, Geographic Overlap, and Roost Sharing Shape Parasite Communities in European Bats

Host Phylogeny, Geographic Overlap, and Roost Sharing Shape Parasite Communities in European Bats

Investigation of Bartonella spp. in brazilian mammals with emphasis on rodents and bats from the Atlantic Forest

Bat Flies and Their Microparasites: Current Knowledge and Distribution

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