Bartonella Species Bacteremia in Two Patients with Epithelioid Hemangioendothelioma

Abstract

Bartonella henselae and B. koehlerae bacteremia was documented in two epithelioid hemangioendothelioma patients and B. koehlerae bacteremia in an asymptomatic partner of one of the patients. Considering the biology and clinically variable natural history of epithelioid hemangioendothelioma, these results suggest that chronic Bartonella infection could have a role in the development of this vascular neoplasm. Bartonella spp. are known to induce vasoproliferative tumors in immunocompromised patients and may play a role in the development of epithelioid hemangioendothelioma in immunocompetent patients.

Infection with Bartonella henselae in a Danish Family

“…In this report and other cases reported to date (8)(9)(10)(11)(12), the route(s) of transmission to or among family members remains unclear. The mode(s) of transmission may vary among and within families depending on environmental, social, microbiological, and epidemiological factors.…”

“…In Australia, the male partner of a woman who was infected with B. henselae, B. koehlerae, and B. vinsonii subsp. berkhoffii subsequently was found to be infected with B. koehlerae (11). Infection with B. henselae also was documented in two of four family members from the Netherlands (12).…”

“…As previously described (11)(12)(13)(14) (15). Heavily infected cell cultures were spotted onto 30-well Teflon-coated slides (Cel-Line/Thermo Scientific, Waltham, MA), air dried, acetone fixed, and stored frozen until tested.…”

Hemangioendotelioma epitelioide pulmonar: Reporte de un caso

“…La distribución según género es de 1:4 mayor en mujeres [5][6][7] . Su etiología está aún en estudio, se asocia a moduladores de la angiogénesis y a la Proteína de Quimiotaxis de Monocitos 1, que serían necesarios para la proliferación tumoral, a su vez, Budousquie et al describieron gran variedad de alteraciones clonales destacando translocación 7 y 22, translocaciones robertsonianas del cromosoma 14 y la pérdida del cromosoma Y [8][9][10] . Actualmente se ha relacionado la infección por Bartonella (B. henselae, B. quintana, B. bacilliformis) al desarrollo de este tumor.…”

Identification of Novel Zoonotic Activity of Bartonella spp., France

“…from human samples using an in-house technique based on results of blood pre-enrichment followed by PCR detection of Bartonella spp. ; members of the same team have investigated many cases of persons who had nonspecific symptoms, including arthralgia, muscle pain, fatigue, headaches, visual blurring, neurocognitive symptoms, and, in 2 case-patients, hemangioendothelioma (30). In total, B. henselae DNA was detected in 47 cases (5,(30)(31)(32)(33); B. koehlerae (another common agent of feline bacteremia) DNA in 96 cases, including 2 co-infected with B. henselae (31,32,34,35); and B. vinsonii berkhoffii (an agent of canine bacteremia and endocarditis) DNA in 24 cases (31-34), including 16 case-patients with B. henselae and 2 cases of B. melophagi (36).…”