2010
DOI: 10.1136/hrt.2010.205781.53
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BAS/BSCR42 Effect of p38-  gene silencing on cytokine and matrix metalloproteinase expression by human cardiac myofibroblasts

Abstract: Cardiac myofibroblasts (CMF) have a key role in the remodelling of the heart that occurs following a myocardial infarction. This remodelling can be initiated by increased myocardial levels of proinflammatory cytokines (eg, interleukin (IL)-1), that can stimulate cardiac myofibroblasts to express other proinflammatory cytokines and matrix metalloproteinases (MMPs). The p38 mitogen-activated protein kinase (MAPK) signalling pathway is also known to be detrimental in the myocardial remodelling process. There are … Show more

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