Basal and forskolin-stimulated cyclic adenosine monophosphate in intact human platelets during the menstrual cycle

Pansini, F.; Piccolo, R. Lo; Bassi, P; N, Guzzinati; Jacobs, M.; Ambrosecchia, R.; Bergamini, Carlo M.; Mollìca, G.

doi:10.1016/0002-9378(86)90629-0

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…How the responsiveness of the calcitonin receptors to the hormone is modified by the endogen¬ ous steroids is not clear, but it is probably pertinent to recall that several adenylate cyclase-coupled receptors appear to be modulated by steroids; for instance, 1,25-dihydroxyvitamin D, dexamethasone and corti¬ sol affect the cyclase activity of monocyte-like cells, ROS 17/2.8 cells in culture and adrenal membranes (Cook, Najafizadeh & Solanki, 1984;Rubin & Catherwood, 1984;Rodan, Fischer, Egan et al 1984). Endometrial cells (Bergamini, Pansini, Bettocchi et al 1985) and platelets (Pansini, Piccolo, Bassi et al 1986) have also been shown to have adenylate cyclase sys¬ tems which are sensitive to the levels of endogenous hormones. The present study, therefore, provides an additional example of regulation of cell adenylate cyclase by steroid hormones.…”

Section: Discussionmentioning

confidence: 99%

Ovarian steroids modulate the action of calcitonin in women

Pansini

Bergamini²,

Bellinazzi³

et al. 1988

Journal of Endocrinology

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Slow i.v. infusion of salmon calcitonin into normal women led to a transient increase in plasma concentrations of cyclic AMP and to a decrease in plasma calcium, which was maintained for at least 2 h. These responses were significantly reduced in the same patients after hysterectomy and ovariectomy. In contrast, maintenance of the ovaries at the time of surgery, or substitutive hormonal therapy, seemed to restore the sensitivity to exogenous calcitonin, suggesting a permissive role of ovarian steroids in the effect of calcitonin. The most likely explanation for this phenomenon is that these hormones influence either the number of calcitonin receptors or the coupling of the receptors to the functional unit of bone adenylate cyclase.

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Section: Discussionmentioning

confidence: 99%

Ovarian steroids modulate the action of calcitonin in women

Pansini

Bergamini²,

Bellinazzi³

et al. 1988

Journal of Endocrinology

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Platelet prostaglandin E1 hyposensitivity in schizophrenia: Reduction of prostaglandin E1- or forskolin-stimulated cyclic AMP response in platelets

Ofuji

Kaiya²,

Nozaki

et al. 1989

Life Sciences

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Effects of Abstinence and Family History for Alcoholism on Platelet Adenylyl Cyclase Activity

Menninger

Barón

Tabakoff

1998

Alcoholism Clin & Exp Res

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Platelet adenylyl cyclase (AC) activity was measured in 32 alcohol-dependent subjects and 27 control subjects who were categorized as either family history-positive (FHP) or family history-negative (FHN) for alcoholism. The interview and blood sample collections were performed shortly after cessation of heavy drinking in the alcoholic group, and repeat blood samples were obtained at the end of the first and second weeks of monitored abstinence. Control subjects received the same interview and provided blood samples at the time of the interview. When subjects were not segregated for FHP or FHN status, there were no statistically significant differences in basal, cesium fluoride (CsF)-, or forskolin-stimulated mean AC activities between the controls and the alcoholics, at study entry or with 1 or 2 weeks of abstinence. On the other hand, over the 2-week course of sobriety from heavy drinking, the CsF-stimulated AC activity of FHP alcohol-dependent subjects decreased significantly (p = 0.03). FHP alcohol-dependent subjects after 2 weeks of sobriety had significantly lower mean CsF-stimulated AC activity than FHN controls (p = 0.04), whereas the FHN alcoholic subjects' CsF-stimulated AC activity did not differ significantly from FHN controls at this point in time. When all subjects were pooled and then categorized as either FHP or FHN, there was a significant difference in mean CsF-stimulated AC activity (p = 0.02) between the FHP and FHN subject groups. Genetic factors and abstinence appear to have roles in determining low platelet AC activity in alcoholic and nonalcoholic subjects. CsF-stimulated platelet AC activity, in particular, appears to act as a trait marker for a genetic vulnerability to developing alcoholism, but recent heavy drinking in male alcoholics is a factor that can mask differences between FHP and FHN subjects.

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Basal and forskolin-stimulated cyclic adenosine monophosphate in intact human platelets during the menstrual cycle

Cited by 5 publications

References 9 publications

Ovarian steroids modulate the action of calcitonin in women

Ovarian steroids modulate the action of calcitonin in women

Platelet prostaglandin E1 hyposensitivity in schizophrenia: Reduction of prostaglandin E1- or forskolin-stimulated cyclic AMP response in platelets

Effects of Abstinence and Family History for Alcoholism on Platelet Adenylyl Cyclase Activity

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