Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori

Gisbert, Javier P.; Boixeda, D; Al-Mostafa, Abeer; Vila, T; L, de Rafael; Baleriola, Alvarez; Argila, de; Abraira,

doi:10.1097/00042737-199902000-00022

Cited by 21 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous studies, the level of gastrin after successful eradication of H. pylori has been followed up only for 2 years . In most patients with successful eradication, the serum level of gastrin decreases 1–6 months after completing the eradication regimen and remains unchanged for 1–2 years . In the present study, the level of serum gastrin in patients who achieved successful eradication more than 2 years ago was similar to that of uninfected subjects.…”

Section: Discussionsupporting

confidence: 72%

“…In the present study, we also studied the association between the level of gastrin and duration after successful eradication. In previous studies, the level of gastrin after successful eradication of H. pylori has been followed up only for 2 years . In most patients with successful eradication, the serum level of gastrin decreases 1–6 months after completing the eradication regimen and remains unchanged for 1–2 years .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decrease of serum level of gastrin in healthy Japanese adults by the change of Helicobacter pylori infection

Shimoyama

Chinda

Matsuzaka

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim: In Japan, the prevalence of Helicobacter pylori infection is decreasing and the number of patients who receive eradication therapy is increasing. Although the serum level of gastrin is affected by H. pylori infection, the normal level has been unchanged for more than 20 years. The aim of this study was to study whether the present normal range for the serum gastrin level is appropriate for Japanese at present or in the near future. Methods: We studied 810 adults (40-80 years old) who participated in a health survey in 2012. We measured H. pylori stool antigen, titer of serum antibody to H. pylori, and serum level of gastrin. The patient's H. pylori status was defined as positive or negative when the results of both stool antigen and serology were concordant. Subjects who were taking proton-pump inhibitor and had a previous history of gastric surgery were excluded. Results: Mean serum level of gastrin was 66.2 ± 49.6 pg/mL in 281 H. pylori-negative subjects and 69.7 ± 42.2 pg/mL in 115 patients who had H. pylori eradicated at least 2 years ago. The level of gastrin was 134.4 ± 145.6 pg/mL in 224 patients with H. pylori infection and the level was significantly higher when compared with those in uninfected subjects and eradicated patients (P < 0.01). Conclusions: Because the situation of H. pylori infection has changed remarkably in Japan, a new appropriate normal range of gastrin should be established using current Japanese populations.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Decrease of serum level of gastrin in healthy Japanese adults by the change of Helicobacter pylori infection

Shimoyama

Chinda

Matsuzaka

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Generally, it has been accepted that the decrease in PgII is observed already 1 month after H. pylori eradication [8][9][10] whereas the decrease in PgI levels occurs progressively during 6 months, remaining unchanged within a period of 1 year [11]. The decrease in PgI and PgII is further associated with an increase in the PgI/PgII ratio [7,12].…”

Section: Discussionmentioning

confidence: 99%

Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection

Daugule

Ruskule²,

Moisejevs³

et al. 2015

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

show abstract

“…After eradication of H. pylori infection with antibiotics and regression of inflammation, both pepsinogens decreased after a few weeks [12–21] and remained unchanged over one year [16, 17, 21]. …”

Section: Discussionmentioning

confidence: 99%

Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and afterH. pyloriEradication

Massarrat

Haj-Sheykholeslami

Ashraf

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Background. The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication. Methods. First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years after H. pylori eradication. The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n = 369), after eradication (n = 115), and in those with persistent infection (n = 250). Results: After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values. Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change. After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL), higher pepsinogen II (9.4 versus 6.9 μ/mL), and lower ratio (7.9 versus 11.6) than those without (P < 0.05). Conclusion. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.

show abstract

Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori

Cited by 21 publications

References 0 publications

Decrease of serum level of gastrin in healthy Japanese adults by the change of Helicobacter pylori infection

Decrease of serum level of gastrin in healthy Japanese adults by the change of Helicobacter pylori infection

Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection

Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and afterH. pyloriEradication

Contact Info

Product

Resources

About