2022
DOI: 10.3389/fendo.2022.875865
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Basal and Stress-Induced Network Activity in the Adrenal Medulla In Vivo

Abstract: The adrenal medulla plays a critical role in mammalian homeostasis and the stress response. It is populated by clustered chromaffin cells that secrete epinephrine or norepinephrine along with peptides into the bloodstream affecting distant target organs. Despite been heavily studied, the central control of adrenal medulla and in-situ spatiotemporal responsiveness remains poorly understood. For this work, we continuously monitored the electrical activity of individual adrenomedullary chromaffin cells in the liv… Show more

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Cited by 7 publications
(2 citation statements)
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“…The spontaneous electrical activity reported in isolated mouse (Marcantoni et al., 2009) and rat (Marcantoni et al., 2023) CCs as well as mouse (Milman et al., 2021; Nassar‐Gentina et al., 1988; Voets et al., 1999) and rat adrenal gland slices (Albinana et al., 2015; Barbara et al., 1998; Kajiwara et al., 1997; Lopez Ruiz et al., 2022; Martin et al., 2001, 2003) might be responsible for tonic CA release. However, sympathetic nervous system activation lead to MCCs nicotinic ACh receptor‐mediated Na + influx and rapid membrane depolarization that neurogenically augments the electrical activity and vesicle exocytosis.…”
Section: Resultsmentioning
confidence: 99%
“…The spontaneous electrical activity reported in isolated mouse (Marcantoni et al., 2009) and rat (Marcantoni et al., 2023) CCs as well as mouse (Milman et al., 2021; Nassar‐Gentina et al., 1988; Voets et al., 1999) and rat adrenal gland slices (Albinana et al., 2015; Barbara et al., 1998; Kajiwara et al., 1997; Lopez Ruiz et al., 2022; Martin et al., 2001, 2003) might be responsible for tonic CA release. However, sympathetic nervous system activation lead to MCCs nicotinic ACh receptor‐mediated Na + influx and rapid membrane depolarization that neurogenically augments the electrical activity and vesicle exocytosis.…”
Section: Resultsmentioning
confidence: 99%
“…In trauma patients, hemodynamic stability is achieved through adequate volume resuscitation and the use of vasoactive drugs. Various types of stimuli (trauma, hypovolemia, pain, anxiety, in ammation, stress, and infections) increase activity in the sympathetic nervous system, resulting in epinephrine release by the adrenal medulla as an adaptive response [9][10][11]. Emergency surgery, whether in the setting of trauma or not, increases sympathetic nervous system activity.…”
Section: Discussionmentioning
confidence: 99%