Basal and TRH induced thyreotropin in neutral goiter: dependence upon duration of illness, lack of response in 3 out of 62 patients

Abstract

Stimulation of growth hormone by oral clonidine. We don't have the ideal test wich permit us know the pituitary reserve of GH.We studied the effect of the clonidine in 1 6 healthy children whose ages were from 6-15 years old and in 3 with hypopituitarism. The dose used was of 0.005 mgfkg given orally.We obtained blood samples to measure the GH (in the normal children samples were also taken for glucose in ten of them, and for insulin, TSH and prolactin in all of them) at 0, 4 0 , 6 0 , 90, 1 2 0 , and 1 4 0 min.At the same time and at the 1 8 0 min. the blood-pressure was measured. In the healthy one we obtained and increaae of the plasvtic levels of GH of 2.51 SM) and T t o g e t h e r w i t h body w e i g h t were examined. I n t h e C A -t r e a t e d a n i m a f s body w e i g h t and i t s v e l o c i t y were suppressed. When CA was withdrawn a t d i f f e r e n t phases o f m a t u r a t i o n , catch-up growth was c b s e r v e d a t a l l t i m e -p o i n t s e x c e p t age day 80. The C A -t r e a t e d a n i m a l s showed m u l t i p l e e f f e c t s on t h e i r hormonal l e v e l s : FSH b e i n g i n c r e a s e d a t a l l t i m e -p o i n t s , LH i n c r e m e n t a f t e r day 30 t h e n i nc r e a s i n g and DHA i n c r e a s i n g a f t e r day 30. I n c o n t r a s t t o t h e findirgs i n humans, t h e a n t i g o n a d o t r o p i c e f f e c to f CA seen i n p r e p u b e r t a l a n i m a l s was l a t e r overcome by a n t i a n d r z g e n i c e f f e c t . M. ROGER. M. BROYER;: K. S C H .).From Nap 1978 u r l t i l Febl-uary 1980, 758,571 newbozns were screened, r e p r e s e n t i n g a screrrilng r a t e of approxiaately 90% of a l l i.nfun-ts born i n I s r a e l . During t h i s pried 49 p r inlsrj c e o n a t a l hypothyroi8 i n f a n t s were d e t e c t e d , an incidence of 1:$300. "!ere A-abs and 31 were of Jewish 0r.ig-i n. There was no sex riifference. During t h e uanie period 45 PBG-d. neonates were d s t e c t e d (1:3500), t h e h i g h e s t i n c i d e n :~ reported u n t i l cow. 22 were kca't)s arid 2: of Jewish orie;in. The sex r a t i o K:F was 8 I;o 1 sllrgesting an x-linked .in:?eritsnce. 1 2 of t t c T B G~~ wzre from two adjacent Arab irillages. 11) one of t h e s e v i l l a g e s with a pop111ati.on of 4000 ve oturt e d a t o t s 1 popallat5 cn screening progran. I n 2 of t h e extended faml.11.e~ ("Heuula"), where intermnrriege i s a custom, we already found 7 komozygote females who a r e TBG d e f i c i e n t . Thus, co.:~sanguinity i n t h e s e Arab f a m i l i e s might be t h e c a m e o l t h e high i n c idome of T5S-d iti t h e A.?ab population a r~d explain t h e very high incidence of T9G-d i.n I s r a e l .

Pituitary Is Not Required for the Compensatory Thyroid Hyperplasia

“…Delange et al [3] found that, in case of endemic goiter in humans, there is no correlation between TSH level in blood serum and the thyroid size and function. Romer et al [20] have reported that the increase of TSH concentration level has no significance in the pathomechanism of neutral goiter formation in children. Naeije et al [17] have proved that in the con ditions of experimental iodine deficiency in rats the thyroid enlargement takes place, which is at first, accompanied by a nonincreased TSH level in blood serum.…”