Basal Cell Adenocarcinoma Arising from the Parotid Gland

Vitorino, Marina; Tinoco, Joaquim; Chaves, Andreia Filipa

doi:10.1159/000528090

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Surgery with clear, free surgical margins is always the goal of all head and neck surgeons and is the curative method in the majority of cases [19]. In our case, the primary surgery was performed with close margins due to a lack of definitive diagnosis and staging, and the patient came back with a local recurrence within two years.…”

Section: Discussionmentioning

confidence: 87%

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

Alzahrani

2023

Cureus

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Basal cell adenoma is encountered in the salivary glands, particularly the parotid gland; however, malignant transformation is rare, and recurrence is much rarer. We report the case of a 60-year-old man who had experienced a slow-growing mass in the parotid gland, which was suspected to be pleomorphic adenoma. Radiological and cytological examination suggested an atypical lesion in the left parotid. The final diagnosis reached on the excised specimen was that of a basal cell adenocarcinoma ex adenoma with close margins. The patient presented with a recurrence after two years. Routine histopathological examination with careful examination by the pathologist is essential for proper management of such rare malignant lesions, and recurrence is a possibility. A complete excision of the tumor with tumor-free margins from the beginning is suggested.

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Section: Discussionmentioning

confidence: 87%

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

Alzahrani

2023

Cureus

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“…Nonetheless, a subset of BCC occurrences is discernibly distinct, arising in glandular structures, where the traditional influence of UV radiation may not be as pronounced. 15 , 16 …”

Section: Discussionmentioning

confidence: 99%

Basal cell carcinomas of the areola-nipple complex: Case report and review of the literature

Mouadin,

Tahiri El Ousrouti,

Boukansa

et al. 2024

SAGE Open Medical Case Reports

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Basal cell carcinoma of the areola-nipple complex poses diagnostic and therapeutic challenges due to its rarity and unique anatomical location. This subtype of basal cell carcinoma necessitates meticulous management to address potential recurrence and metastasis. Surgical excision with clear margins remains the cornerstone treatment for basal cell carcinoma of the areola-nipple complex, while alternative modalities such as radiation therapy, Mohs surgery, and systemic therapies may be considered in specific cases. However, optimal management strategies remain contentious, with varying opinions on the necessity of aggressive surgical intervention to minimize recurrence and metastasis risks. Additionally, the absence of standardized diagnostic criteria and treatment guidelines complicates clinical decision-making. Herein, we present a rare case of basal cell carcinoma of the areola-nipple complex in a 47-year-old woman with a notable medical history of hypertension, type 2 diabetes, and untreated psychosis, alongside a family history of breast cancer in her aunt. The patient exhibited a non-regressing ulceration on the right areolar region of the breast, persisting for approximately 10 years and progressively extending over time. Following surgical excision, a favorable post-therapeutic course was observed during follow-up. This case underscores the diagnostic challenges and nuanced management considerations inherent in basal cell carcinoma of the areola-nipple complex, underscoring the imperative for tailored treatment approaches.

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Activation of Wnt/β-catenin signalling by mutually exclusiveFBXW11andCTNNB1hotspot mutations drives salivary gland basal cell adenoma

Wong,

Bishop,

Weinreb

et al. 2024

Preprint

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Wnt signalling must be 'just right' to promote tumour growth. Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland are rare tumours that can be difficult to distinguish from each other and other salivary gland tumour subtypes. Due to their rarity, the genetic profiles of BCA and BCAC have not been extensively explored. Using whole-exome and transcriptome sequencing of BCA and BCAC cohorts, we identify a novel recurrentFBXW11missense mutation (p.F517S) in BCA, that was mutually exclusive with the previously reportedCTNNB1p.I35T gain-of-function (GoF) mutation. These driver events collectively accounted for 94% of BCAs.In vitro, mutant FBXW11 had a dominant negative affect, characterised by defective binding to β-catenin and the accumulation of β-catenin in cells. This was consistent with the nuclear expression of β-catenin observed in BCA cases harbouring theFBXW11p.F517S mutation and activation of the Wnt/β-catenin pathway. The genomic profiles of BCAC were distinct from BCA, with hotspotDICER1andHRASmutations and putative driver mutations affecting PI3K/AKT and NF-κB signalling pathway genes. A single BCAC, which may represent a malignant transformation of BCA, harboured the recurrentFBXW11mutation. These findings have important implications for the diagnosis and treatment of BCA and BCAC, which, despite histopathologic overlap, may be unrelated entities.

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Basal Cell Adenocarcinoma Arising from the Parotid Gland

Cited by 3 publications

References 11 publications

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

Basal cell carcinomas of the areola-nipple complex: Case report and review of the literature

Activation of Wnt/β-catenin signalling by mutually exclusiveFBXW11andCTNNB1hotspot mutations drives salivary gland basal cell adenoma

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