Basal cell adenocarcinoma arising in salivary gland metaplasia of the breast: a novel salivary gland–type tumor developing in the breast

Flynn, Christopher; Kadivar, Maryam; Kwon, Meeae Y.; Bonzanini, Mariella; Haines, G. Kenneth; Tavassoli, Fattaneh A.

doi:10.1016/j.humpath.2012.02.013

Cited by 6 publications

(5 citation statements)

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“…Previous studies demonstrated that TFF1 and TFF3 enhanced cell proliferation and promoted cell migration and invasion in mammary carcinoma cell lines [40,41], whereas TFF2 stimulated cell migration and inhibited apoptosis in breast adenocarcinoma cell lines [42,43]. It has been reported that several salivary gland tumors share similar morphologic features with mammary gland tumors [21][22][23]. It would be of interest to investigate the functional role of TFFs in salivary gland tumors as compared with the mammary gland tumors in order to evaluate whether TFFs may have context-specific functions in different tissue compartments.…”

Section: Discussionmentioning

confidence: 99%

“…Pleomorphic adenoma is common as benign salivary gland tumors, whereas mucoepidermoid carcinoma and adenoid cystic carcinoma are common as malignant salivary gland tumors [19]. Similar morphologic features between salivary and mammary gland tumors such as mucoepidermoid carcinoma, adenoid cystic carcinoma, and basal cell adenocarcinoma have been reported [21][22][23]. Moreover, previous studies demonstrated the involvement of TFF1 and TFF3 genes in mammary gland tumors, and these two genes were used as biomarkers for detecting disseminated malignant cells of breast cancer [24][25][26].…”

Section: Introductionmentioning

confidence: 95%

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Increased immunoexpression of trefoil factors in salivary gland tumors

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Increased immunoexpression of trefoil factors in salivary gland tumors

et al. 2013

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“…Regional and distant metastasis rates are 8-12% and 2-4%, respectively. 15,94 Basal cell adenocarcinoma is a rarely reported entity in literature. In 2012, Flynn et al published a case series of three cases of basal cell adenocarcinoma arising in salivary gland metaplasia of the breast.…”

Section: Basal Cell Adenocarcinomamentioning

confidence: 99%

“…But due to the paucity of literature, it is difficult to conclude the prognosis and outcome of these tumors. 93,94 Very few studies evaluated the hormone receptor status of basal cell adenocarcinoma. Nasser et al showed few cases having positivity to AR.…”

Section: Basal Cell Adenocarcinomamentioning

confidence: 99%

A Systemic Review on Similarities between Salivary and Mammary Gland Neoplasms and the Role of Antihormonal Therapy in Salivary Gland Tumors

Ganga¹,

Ramachandrappa²,

Shamanna³

2023

International Journal of Head and Neck Surgery

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The matured salivary gland contains two types of cells, both luminal and abluminal cells. The luminal cells include acinar and ductal cells. The abluminal cells are myoepithelial and basal cells. 4 Unlike salivary glands, mammary glands undergo complex epithelial remodeling throughout puberty, pregnancy, lactation, and weaning. The mammary gland is a highly branched ductal structure having luminal cells and myoepithelial cells. 5 Each cell type in both mammary and salivary glands express a variety of markers that helps in the identification and characterization (Table 1) and (Table 2). [6][7][8] Salivary gland tumors are distinct in their wide variety of subcategorization and rarity in occurrence. The two most widely IntroductIonSalivary glands are complex tubuloacinar exocrine or merocrine glands mainly secrete saliva. The parotid gland is ectodermal, while submandibular and sublingual glands are endodermal in origin. All the minor salivary glands have mixed origins with both ectodermal and endodermal components. The epithelial cells determine the type of secretion produced by the gland and the mesenchymal cells contribute to the morphology of the gland. 1 Each developed gland consists of parenchyma, glandular secretory tissue, and stroma. The secretory units contain secretory cells which organize to form clusters called acini. These units can be either of the three types-mucinous, serous, and seromucinous. The secretions pass through the intercalated ducts, striated, excretory duct, and finally main excretory duct opening into the oral cavity. 2 The mammary gland contains both ectodermal and mesodermal components. The ectoderm forms a mammary line which resolves into placodes. These placodes invaginate into the mesenchyme and form the rudimentary ductal structure. The embryonic mammary mesenchyme provides the key signals for epithelial cell differentiation. This epithelial differentiation was demonstrated in reciprocal tissue recombination experiments in which 12 and 16th-day-old embryonic mammary epithelium was combined with salivary mesenchyme and grown in culture. These tissue recombinants produced epithelium that was morphologically resembling salivary glands. The rudimentary ductal system forms the terminal end buds which later differentiate to form myoepithelial cells. This system will develop into terminal ductolobular units with acini which are mainly mediated by hormones. 3

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“…Basal cell adenocarcinoma (BCAC) is a rare, low-grade malignant tumor that typically affects the parotid gland, followed by the submandibular gland and minor salivary glands of the upper aerodigestive tract. 1 Involvement of the lacrimal gland, 2 supraglottic larynx, 3 breast, 4 tongue, 5 and ethmoid sinus 6 have been reported. Diagnosis of basal cell adenocarcinoma can be challenging due to overlapping histomorphologic features with its benign counterpart, basal cell adenoma, as well as the more aggressive malignant salivary gland tumor, adenoid cystic carcinoma.…”

Section: Introductionmentioning

confidence: 99%