Basal cell adenocarcinoma of the major salivary glands: A population‐level study of 509 cases

Zhan, Kevin Y.; Lentsch, Eric J.

doi:10.1002/lary.25713

Cited by 33 publications

(19 citation statements)

References 27 publications

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“…Among tumors originating from the salivary gland(s), EMC and BCAC are rarely observed low-grade malignant tumors, which often arise from the parotid gland. In 1991, these were classified as independent diseases under the World Health Organization classification [8]. EMC has biphasic pathological characteristics involving variable proportions of two distinct cell types.…”

Section: Discussionmentioning

confidence: 99%

Metachronous malignant tumors in ipsilateral salivary glands

Kwon¹,

Kim²,

Rhie³

et al. 2019

Arch Craniofac Surg

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Salivary gland tumors usually appear in solitary mass in single salivary gland. The coexistence of tumors with different histological types occurring within a unilateral parotid gland is an extremely rare event. We experienced a case which two different types of malignant tumors developed at different time points in same gland; metachronous tumors. The second tumor was excised widely and reconstruction was performed by free tissue transfer. Sensory and motor nerve to the left cheek appeared to be intact, and circulation was adequate. This rare case was presented in this article.

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Section: Discussionmentioning

confidence: 99%

Metachronous malignant tumors in ipsilateral salivary glands

Kwon¹,

Kim²,

Rhie³

et al. 2019

Arch Craniofac Surg

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“…Surgical excision with a wide margin to ensure complete tumour removal has been recommended as the mainstay of treatment for BCAC of the major salivary glands. Regional lymph node dissection is indicated only in cases involving cervical lymph nodes [ 3 , 4 , 15 – 17 ]. BCAC affecting the minor salivary glands are more infiltrative than lesions affecting the major salivary glands [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature

Jin

2018

BMC Cancer

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BackgroundBasal cell adenocarcinomas (BCACs) arise from the minor salivary glands in the upper respiratory tract and are extremely rare. In this report, we present an unusual case of a 57-year-old male with BCAC that arose from the nasopharynx. To our knowledge, this is the first case report of nasopharyngeal BCAC.Case presentationIn August 2010, a 57-year-old Chinese male presented with epistaxis and decreased hearing for 1 month. He was diagnosed with BCAC of the solid type that arose from the nasopharynx. The patient received radiotherapy alone and exhibited a complete response. A follow-up at 72 months did not detect any evidence of disease recurrence or metastasis. A comprehensive literature review revealed only 7 previously reported cases of BCAC in the upper respiratory tract. Surgery is the first choice to treat BCAC but may impair maxillofacial function. Radiotherapy is reserved for inoperable cases.ConclusionsRadiotherapy can achieve good local control and preserve maxillofacial function; therefore, this treatment may be a suitable option for patients who are not good candidates for surgery.

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“…Basal cell adenocarcinoma (BAC) of the salivary gland is a rare carcinoma, accounting for approximately 1% of all salivary gland carcinomas, with a good prognosis. 1 Because of the rarity of this tumor, little is known about the cytological features of BAC, with most of the published literature comprising single cases or small case series. [2][3][4][5][6][7][8] Recently, we analyzed the cytological features of basal cell adenoma of the salivary glands, and clearly demonstrated that the detection of stromal spindle cells was very useful in the diagnosis of basal cell adenoma.…”

Section: Introductionmentioning

confidence: 99%

“…Basal cell adenocarcinoma (BAC) of the salivary gland is a rare carcinoma, accounting for approximately 1% of all salivary gland carcinomas, with a good prognosis . Because of the rarity of this tumor, little is known about the cytological features of BAC, with most of the published literature comprising single cases or small case series …”

Section: Introductionmentioning

confidence: 99%

Cytological features of basal cell adenocarcinoma of the salivary glands

Ishida

Okano

Sandoh

et al. 2019

Diagnostic Cytopathology

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The cytological features of basal cell adenocarcinoma (BAC) of the salivary gland, a rare carcinoma, have not been well described. This study included patients who were histopathologically diagnosed with BAC and who underwent preoperative fine‐needle aspiration cytological examination. Cytological characteristics, including background, arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and presence of stromal spindle cells, were reviewed. Seven patients were enrolled in the study. The cytological specimens were cellular and composed of large or small clusters with occasional discohesive neoplastic cells at the periphery. The predominant cellular morphology was spindle‐shaped in four cases, and small round‐shaped in three cases. These neoplastic cells were tightly packed, showed high cellularity and overlapping nuclei, and had mildly to moderately enlarged round to oval nuclei with occasional small nucleoli and scant cytoplasm. Stromal spindle cells were observed around the basaloid cells in three cases (42.9%). All histology‐proven stromal spindle cell‐positive cases had stromal spindle cells in the cytological specimens. The study findings clearly demonstrate the relatively high frequency of stromal spindle cells in cytological specimens of BAC. This finding is characteristic of BAC, although basal cell adenoma of salivary gland frequently has stromal spindle cells in the cytological specimens. The characteristic that differentiates BAC from basal cell adenoma is the presence of tightly packed and high cellular clusters with discohesive neoplastic cells. An understanding of these cytological features can aid the cytodiagnosis of BAC.

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Basal cell adenocarcinoma of the major salivary glands: A population‐level study of 509 cases

Abstract: 4. Laryngoscope, 126:1086-1090, 2016.

Cited by 33 publications

References 27 publications

Metachronous malignant tumors in ipsilateral salivary glands

Metachronous malignant tumors in ipsilateral salivary glands

Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature

Cytological features of basal cell adenocarcinoma of the salivary glands

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