Basal Cell Carcinoma Arising from an Epidermal Cyst: When a Cyst Is Not a Cyst

Liau, Jia Li; Altamura, Davide; Ratynska, Marzena; Verdolini, Roberto

doi:10.1159/000381393

Cited by 15 publications

(13 citation statements)

References 6 publications

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“…Carcinogenesis is ubiquitous and it is therefore not surprising that other skin cancers have been reported to develop in epidermal inclusion cysts, but to a far lesser extent. Neoplasms such as Basal cell carcinoma, Mycosis Fungoides, Merkel Cell carcinoma and Melanomas have been reported to originate from epidermal inclusion cysts, but to a far lesser incidence than squamous cell carcinoma [1,[5][6][7]. This may be so since the main promoting agent of these skin carcinomas, namely ultraviolet radiation, [2,8] is not accessible to epidermal inclusion cysts in their deep dermal locations.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma developing in an epidermal inclusion cyst

Daisley¹

2019

Our Dermatol Online

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Epidermal inclusion cysts and squamous cell carcinoma of the skin are very common pathological lesions. However a squamous carcinoma arising in an epidermal inclusion cyst is a rare finding. We present a case of the malignant transformation of an epidermal inclusion cyst into a squamous cell carcinoma over a 25 year period in a 67 year old male. A brief review of the literature and theories postulated as to its histiogenesis are undertaken.

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma developing in an epidermal inclusion cyst

Daisley¹

2019

Our Dermatol Online

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“…Malignant transformation of an epidermoid cyst is a rare event but possible. Squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma have been observed [ 9 ][ 10 ][ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Epidermoid Cysts – A Wide Spectrum of Clinical Presentation and Successful Treatment by Surgery: A Retrospective 10-Year Analysis and Literature Review

Wollina¹,

Langner²,

Tchernev³

et al. 2018

Open Access Maced J Med Sci

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Epidermoid cysts are common benign lesions of hair-bearing, and less often glabrous skin. They can also occur in oral mucosa and internal organs. In case of cutaneous lesions, an epidermal punctum is a clinical diagnostic hallmark. The clinical presentation is variable leading to some differential diagnoses. Diagnosis of epidermoid cysts needs histopathological confirmation – not only of the potential of malignant transformation. The treatment of choice is surgery. We report a retrospective analysis of 2159 epidermoid cysts treated surgically. Most of the cases can be performed under local anaesthesia. The complication rate of 2.2% is low. To avoid relapses, the cyst wall has to be removed completely. Rare genetic disorders with multiple cysts are Gardner and Lowe syndrome.

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“…Even rarely, there is the possibility of malignant transformation in epidermal cysts as in this respect cases are described as switching to squamous cell carcinoma, basal cell carcinoma and Merkel cell carcinoma [2]. For this reason, histological examination is essential and obligatory for the correct interpretation and diagnosis of these epidermal formations [3].…”

Section: Introductionmentioning

confidence: 99%

Multiple Epidermal Cysts of the Scalp: Dermatosurgical Approach with Favourable Outcome!

Tchernev

Temelkova²,

Yungareva

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Epidermal cysts are subcutaneous tissue formations that are most commonly located in the area of scalp, trunk and face. In addition to single ones, the cysts may also be multiple, located near each other. Although they are considered to be a cystic ectasia of the hair infundibulum and mainly affect hairy parts, they can also be seen in the area of palms and feet as a result of trauma. Rare extracutaneous localisations are also described in the medical literature, affecting the oral cavity, intraosseous, cerebrum and sublingual epidermoid cyst. Although the majority of epidermal cysts are benign, a malignant transformation may also occur in the direction of development of squamous cell carcinoma, basal cell carcinoma or Merkel cell carcinoma. Clinically, they are presented as benign lesions, and only histological examination may reveal their malignant potential. Therefore, their surgical removal and subsequent histology are of paramount importance for the elucidation of their origin. CASE PRESENTATION: An 88-year old patient was hospitalized for surgical removal of two tumorous formations in the head area which have been available for many years. During the dermatological examination in the frontal and parietal area of the head, the presence of two oval pink cystic neoplasms, clinically suspected for epidermal cysts, was found. The lesion located in the frontal area was removed by elliptical excision. The resulting surgical defect was closed by undermining the wound edges and mobilisation of the released skin to the middle of the defect, as the latter being closed by single interrupted sutures. In the second surgical session, the lesion located in the parietal region of the head was also removed under local anaesthesia. A so-called island flap was performed in which the tumour formation was removed by oval excision followed by contouring a triangle in the distal direction and transposition of the undermined triangle to the oval surgical defect. The resulting defect was recovered by single interrupted sutures. CONCLUSION: First-line treatment of epidermal cysts is surgical excision, and it is important to remove the cyst wall to minimise the risk of relapses and recurrence. Other treatment options include laser therapy with CO2, erbium-YAG laser or intralesional drainage injection of triamcinolone acetonide.

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Basal Cell Carcinoma Arising from an Epidermal Cyst: When a Cyst Is Not a Cyst

Cited by 15 publications

References 6 publications

Squamous cell carcinoma developing in an epidermal inclusion cyst

Squamous cell carcinoma developing in an epidermal inclusion cyst

Epidermoid Cysts – A Wide Spectrum of Clinical Presentation and Successful Treatment by Surgery: A Retrospective 10-Year Analysis and Literature Review

Multiple Epidermal Cysts of the Scalp: Dermatosurgical Approach with Favourable Outcome!

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