Basal Cell Carcinoma of Scalp in Patients With History of Childhood Therapeutic Radiation

Abstract

BCC in irradiated scalp has a more aggressive behavior and may need a more aggressive surgical resection. Also, these patients should be under close observation because there is a higher chance for tumor recurrence and also new lesions occurring elsewhere in the scalp.

Elevated expression levels of testis-specific genesTEX101andSPATA19in basal cell carcinoma and their correlation with clinical and pathological features

“…Previous studies showed that BCC in irradiated scalp has a more aggressive behaviour and a higher chance for tumour recurrence. 34 However, further research is recommended.…”

New Concepts for Basal Cell Carcinoma. Demographic, Clinical, Histological Risk Factors, and Biomarkers. A Systematic Review of Evidence Regarding Risk for Tumor Development, Susceptibility for Second Primary and Recurrence

“…BCC in irradiated scalp was reported to have a more aggressive behavior that necessitates a wider surgical resection [70]. Hassanpour et al reported that these patients also demonstrated higher rates of tumor recurrence and second primary tumors occurring elsewhere in the scalp, so it has been suggested that these patients should be regularly followed up [70] ( Table 2).…”

Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis

“…Similar to reporting for atomic bomb survivors and hematopoietic cell transplantation, there is an inverse relationship between BCC risk and age at radiation exposure (16, 42, 43). Although BCC is generally characterized by slow growth, minimal soft tissue invasiveness and high cure rates, other studies showed that BCC developed in irradiated scalp skin tended to be more aggressive and more prone to recurrence (44, 46). Studies depicting the molecular mechanism underlying pathogenesis of aggressive radiation-induced BCCs are few.…”