Basal Cell Carcinoma Overlying Long-standing Dermatofibromas

Bryant, James

doi:10.1001/archderm.1977.01640100123028

Cited by 21 publications

(4 citation statements)

References 4 publications

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“…24,25,28,,29,30 In contrast, the occurrence of BCC over DF is extremely rare, with few supporting case reports. [31][32][33][34][35][36][37] Distinction between FI and BCC can be challenging in superficial biopsies, in which the DF is not directly visualized (Table). Both BCC and FI show peripheral palisading 24 and a superficial, budlike growth pattern (Figure 2, A through C).…”

Section: Follicular Induction Over Dermatofibromamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Follicular Induction Over Dermatofibromamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…Basaloid proliferations overlying dermatofibromas may occur and these range from basal cell hyperplasia with follicular differentiation to well-developed basal cell carcinomas. [7][8][9][10][11] Melanocytic proliferations occurring in association with dermatofibromas have been less well documented in the literature. In a report of three cases, Toda et al 12 described three cases of lentiginous melanocytic hyperplasia overlying dermatofibromas and there was an increased frequency of S-100 protein and Mel-5 melanocytes along the basal layer of the epidermis overlying dermatofibromas.…”

Section: Histologic Findingsmentioning

confidence: 99%

Melanocytic lesions associated with dermatofibromas: a spectrum of lesions ranging from junctional nevus to malignant melanoma in situ

2005

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Dermatofibromas are common lesions that are often associated with epidermal hyperplasia and basal layer hyperpigmentation. A single case of lentiginous melanocytic hyperplasia overlying a dermatofibroma has been reported, however, nevi and melanoma have to the best of our knowledge, not been previously reported. We present 14 cases of melanocytic lesions associated with dermatofibromas. The clinical data and hematoxylinand eosin-stained sections were obtained and formalin-fixed, paraffin-embedded tissue was immunostained with antibodies against S-100, Mart-1, Factor XIIIa, and CD117. There were nine females and five males ranging in age from 30 to 64 years and anatomic sites included back (five), arm (six), flank (two), and leg (one). The clinical diagnosis ranged from dermatofibroma to desmoplastic melanoma. Histologically, the melanocytic lesions included junctional, compound, and dermal nevi, and malignant melanoma in situ. In four cases the dermal component appeared to merge with the dermatofibroma. In the case of the melanoma in situ, the dermatofibroma abutted the epidermis. Immunohistochemically, the melanocytic lesions were S-100/ Mart-1 þ , FXIIIa-, and the dermatofibromas were S-100/Mart-1À, FXIIIa þ . Melanocytic neoplasia may appear in association with dermatofibromas. The fibrohistiocytic proliferation may be misinterpreted as a spindle or pleomorphic melanocytic process. Awareness of this association will aid in the correct diagnosis, and immunohistochemical studies will help in the differentiation of these two cell populations.

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“…All the literature reviewed, including the references cited (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), discusses only "induction" of changes in the epidermis overlying histiocytomas. This "induction" is attributed to some chemicals or other "organizers" presumably secreted, excreted or produced by histiocytomas, which affect the epidermis, resulting in production of hair follicle-like tissue.…”

Section: Commentsmentioning

confidence: 99%

Adnexal displacement and regression in association with histiocytoma (dermatofibroma)

Rahbari

Mehregan

1985

J Cutan Pathol

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The literature about the changes occurring in histiocytomas mentions only the possibility of induction of primitive pilosebaceous structures and basal cell epithelioma-like lesions by the histiofibrocytic growth. We suggest here that the histopathologic findings are indicative of regressive changes of the pre-existing cutaneous adnexa resulting in the formation of basal cell epithelioma-like structures.

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Basal Cell Carcinoma Overlying Long-standing Dermatofibromas

Cited by 21 publications

References 4 publications

Histologic Mimics of Basal Cell Carcinoma

Histologic Mimics of Basal Cell Carcinoma

Melanocytic lesions associated with dermatofibromas: a spectrum of lesions ranging from junctional nevus to malignant melanoma in situ

Adnexal displacement and regression in association with histiocytoma (dermatofibroma)

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