Basal Cell Carcinoma Perineural Invasion and Suggestive Signs of Perineural Invasion—Findings and Perspectives

Niculet, Elena; Bobeica, Carmen; Onisor, Cristian; Gurau, Gabriela; Nechita, Aurel; Radaschin, Diana Sabina; Tutunaru, Dana; Bujoreanu-Bezman, Laura; Tatu, Alin Laurentiu

doi:10.3390/life13061406

Cited by 3 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is important to note that one of the patients’ lesions was located on the nasal area. The nose is a favored site for perineural invasion (PNI) in BCC [ 37 , 38 ]. Perineural invasion in BCC is an important pathological finding in which tumor cells invade the spaces surrounding nerves.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety

Calik,

Sauer,

Woźniak

et al. 2024

JCM

View full text Add to dashboard Cite

Background: The rising incidence of Basal Cell Carcinoma (BCC), especially among individuals with significant sun exposure, underscores the need for effective and minimally invasive treatment alternatives. Traditional surgical approaches, while effective, often result in notable cosmetic and functional limitations, particularly for lesions located on the face. This study explores High-Intensity Focused Ultrasound (HIFU) as a promising, non-invasive treatment option that aims to overcome these challenges, potentially revolutionizing BCC treatment by offering a balance between efficacy and cosmetic outcomes. Methods: Our investigation enrolled 8 patients, presenting a total of 15 BCC lesions, treated with a 20 MHz HIFU device. The selection of treatment parameters was precise, utilizing probe depths from 0.8 mm to 2.3 mm and energy settings ranging from 0.7 to 1.3 Joules (J) per pulse, determined by the lesion’s infiltration depth as assessed via pre-procedure ultrasonography. A key component of our methodology included dermatoscopic monitoring, which allowed for detailed observation of the lesions’ response to treatment over time. Patient-reported outcomes and satisfaction levels were systematically recorded, providing insights into the comparative advantages of HIFU. Results: Initial responses after HIFU treatment included whitening and edema, indicative of successful lesion ablation. Early post-treatment observations revealed minimal discomfort and quick recovery, with crust formation resolving within two weeks for most lesions. Over a period of three to six months, patients reported significant improvement, with lesions becoming lighter and blending into the surrounding skin, demonstrating effective and aesthetically pleasing outcomes. Patient satisfaction surveys conducted six months post-treatment revealed high levels of satisfaction, with 75% of participants reporting very high satisfaction due to minimal scarring and the non-invasive nature of the procedure. No recurrences of BCC were noted, attesting to the efficacy of HIFU as a treatment option. Conclusions: The findings from this study confirm that based on dermoscopy analysis, HIFU is a highly effective and patient-preferred non-invasive treatment modality for Basal Cell Carcinoma. HIFU offers a promising alternative to traditional surgical and non-surgical treatments, reducing the cosmetic and functional repercussions associated with BCC management. Given its efficacy, safety, and favorable patient satisfaction scores, HIFU warrants further investigation and consideration for broader clinical application in the treatment of BCC, potentially setting a new standard in dermatologic oncology care. This work represents a pilot study that is the first to describe the use of HIFU in the treatment of BCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety

Calik,

Sauer,

Woźniak

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Several studies have reported that cSCC can perineurally invade the surrounding soft tissues ( 115 , 116 ); this finding suggests that in contrast to, for example, melanoma, the processes of cancer spread depend less on the lymphatic system and have multiple patterns of invasion ( 117 ). Often, during surgery for cSCC, a tumor that travels via a cranial nerve to the base of the skull is identified ( 118 ), which may be treated via radiotherapy ( 119 ). On pretreatment radiographs, a tumor that has spread to the brain via the cranial foramen may often be visible; nevertheless, it is important to highlight that individuals with such tumors are unlikely to be cured and that such tumors are no longer amenable to surgery ( 120 ).…”

Section: Discussionmentioning

confidence: 99%

Metastatic patterns and treatment options for head and neck cutaneous squamous cell carcinoma (Review)

Iancu,

Fulga,

Vesa

et al. 2024

Mol Clin Oncol

Self Cite

View full text Add to dashboard Cite

According to current predictions, one-fifth of all Americans will develop skin cancer during their lifetime. Cutaneous squamous cell carcinoma (cSCC) most commonly occurs in the head and neck region, which is the area of the body with the highest level of sun exposure. High-risk head and neck cSCC (HNcSCC) is a broad category with numerous high-risk factors that are associated with unfavorable results. In cSCC staging systems, clinical and tumor traits that are likely to result in poor outcomes are identified. Metastasis occurs in ~2.5% of patients with cSCC, most often in the local lymph nodes, and there is some indication that lymph node metastasis has a distinct pattern based on the tumor site. Current findings on tumor molecular targets have suggested the use of systemic treatments, particularly immunotherapy (such as cemiplimab, pembrolizumab and nivolumab), over radiotherapy or chemotherapy for this type of metastasis. However, when used simultaneously with immunotherapy, radiotherapy may be beneficial in the treatment of metastatic HNcSCC by improving the efficacy of immunotherapy. The present review aims to assess the existing literature on metastatic HNcSCC pathways and treatment options, in order to define current and future directions. Notably, there is an urgent need to identify patients who may benefit from local or systemic cancer treatments. The treatment of lymph node metastasis presents a therapeutic challenge and requires comprehensive management.

show abstract

Trichilemmal carcinoma treated by excision combined with photodynamic therapy: a case report and review of literature

Qidiao,

Liu,

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Trichilemmal carcinoma is an extremely rare malignant cutaneous tumor derived from the outer root sheath of the hair follicles, which most commonly occurs in the sun-exposed areas of elderly individuals. This article introduces a case of trichilemmal carcinoma that occurred on the scalp of a 36-year-old male patient, the first case reported and treated with surgical excision combined with photodynamic therapy.

show abstract

Basal Cell Carcinoma Perineural Invasion and Suggestive Signs of Perineural Invasion—Findings and Perspectives

Cited by 3 publications

References 62 publications

Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety

Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety

Metastatic patterns and treatment options for head and neck cutaneous squamous cell carcinoma (Review)

Trichilemmal carcinoma treated by excision combined with photodynamic therapy: a case report and review of literature

Contact Info

Product

Resources

About