Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi

Bu, Wenbo; Chen, Hao; Mengli, Zhang; Zeng, Xuesi; Zhao, Liang; Fang, Fang

doi:10.1111/j.1524-4725.2011.02163.x

Cited by 12 publications

(18 citation statements)

References 10 publications

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“…Several different tumors of epidermal, adnexal, and mesenchymal origin are known to arise (one or more simultaneously [24,25,26]). Benign tumors [12,27,28,29,30,31,32] are the most common neoplasms, including syringocystadenoma papilliferum, apocrine cystadenoma, trichoblastoma, trichilemmal cysts, and keratoacanthoma. Although less common, malignant degeneration [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47] occurs, with a lifetime risk of 5-20%.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases

Kelati

Baybay

Gallouj

et al. 2017

Skin Appendage Disord

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Background: Nevus sebaceus of Jadassohn (NSJ) is a complex cutaneous hamartoma with various clinical appearances. Aim: To describe different dermoscopic patterns of this nevus according to its evolutionary stages. Methods: This was an analytical study of NSJ carried out in the Department of Dermatology at the University Hospital Hassan II, Fez, Morocco. Results: Thirteen patients with a NSJ were enrolled in the study. Elevated verrucous plaques were noticed in 9 patients, homogeneous tumors were described in 2 NSJ, an alopecic patch was found in 1 case, and we had 1 case of malignant transformation into basal cell carcinoma. The dermoscopic aspects of NSJ described in our study were yellowish or brown globules aggregated in clusters on a yellow background. This pattern was significantly related to the first stage of an alopecic patch (p = 0.001). Whitish-yellow lobular aspect and grayish papillary appearance were significantly related to verrucous plaques (p = 0.003). Homogeneous yellow-whitish pattern was related to nodules (p = 0.005). Conclusion: The establishment of specific dermoscopic features of NSJ according to its evolutionary stages is important for its diagnosis and especially its monitoring in order to detect malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases

Kelati

Baybay

Gallouj

et al. 2017

Skin Appendage Disord

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“…entities. The presence of multiple neoplasms in an NS associated with a pigmented melanocytic nevus, 21,22 as seen in our second patient, is much more rare. Wang et al reported a basal cell carcinoma, a syringocystadenoma papilliferum, a tricholemmoma and a sebaceoma, all arising in a NS associated with a melanocytic nevus, thus favoring the hypotheses of a migration anomaly from the neural crest.…”

Section: Discussionmentioning

confidence: 49%

“…Wang et al reported a basal cell carcinoma, a syringocystadenoma papilliferum, a tricholemmoma and a sebaceoma, all arising in a NS associated with a melanocytic nevus, thus favoring the hypotheses of a migration anomaly from the neural crest. 21 Herein, we present two cases of a peculiar apocrine intraductal carcinoma resembling DCIS of the breast. CK7 is usually expressed in metastatic breast carcinoma 23 but may also be expressed in primary cutaneous apocrine tumors.…”

Section: Discussionmentioning

confidence: 99%

Apocrine intraductal carcinoma in situ in nevus sebaceus: two case reports

et al. 2014

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Ductal carcinoma in situ (DCIS) in the mammary glands consists of a proliferation of ductal luminal cells with preserved polarity but lacking the marked intercellular cohesion of hyperplastic cells. We report two cases of DCIS arising in the apocrine glandular structures of a nevus sebaceus (NS). The first patient was a 44-year-old woman with a ductal neoplasm composed of multilayered ductal elements with a monomorphous cellularity and a polar orientation of nuclei. The neoplastic cells were positive for Cm5.2 and CK7. The second patient was a 67-year-old woman with phacomatosis pigmentokeratotica. A skin biopsy of an erythematous plaque within her NS showed an epithelioid monomorphous tumor with eosinophilic and slightly granular cytoplasm. Slight nuclear pleomorphism with some hyperchromatic nuclei was seen. The tumor cells were positive for CK7 and gross cystic disease fluid protein-15. Actin showed a preserved layer of myoepithelial cells in both cases. Our cases are noteworthy, as secondary malignancies or multiple tumors arising in NS are rare, and the presence of multiple neoplasms in phacomatosis pigmentokeratotica is even rarer. Moreover, these tumors expand the spectrum of secondary malignant neoplasms arising in NS, as they closely resemble mammary DCIS.

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“…During the second stage, at the time of puberty, the lesions grow and become verrucous showing large numbers of hyperplastic sebaceous glands microscopically . During the third stage in adulthood, tumors (predominately trichoblastoma and syringocystadenoma papilliferum) form in 10–30% of lesions with the risk of neoplastic transformation increasing with increasing age . In addition to trichoblastoma and syringocystadenoma papilliferum, other benign neoplasms that have been described within nevus sebaceus include tumors of follicular differentiation such as TFI, inverted follicular keratosis, trichilemmoma, desmoplastic trichilemmoma, pilomatricoma, trichoadenoma and proliferating trichilemmal cyst; sebaceous differentiation such as sebaceous adenoma and sebaceoma; apocrine differentiation including apocrine cystadenoma and apocrine adenoma; eccrine differentiation such as syringoma, eccrine poroma and eccrine adenoma; adnexal neoplasms of mixed or uncertain histogenesis such as adenomyoepithelioma, hidradenoma and mixed tumor of the skin; mesodermal origin including piloleiomyoma and osteoma; and neural crest origin such as melanocytic nevus .…”

Section: Discussionmentioning

confidence: 99%

Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet‐ring cells, all arising in nevus sebaceus

2015

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Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. To our knowledge, this is the first report of signet-ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet-ring cell changes in primary cutaneous tumors.

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Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi

Cited by 12 publications

References 10 publications

Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases

Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases

Apocrine intraductal carcinoma in situ in nevus sebaceus: two case reports

Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet‐ring cells, all arising in nevus sebaceus

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