Basal cell carcinomata in port wine stains

Basalzellkarzinome auf mit Radiotherapie vorbehandelten vaskulären Malformationen

“…Eine zurückliegende Therapie von Naevi flammei, also angeborenen vaskulären Malformationen, mit ionisierender Strahlung erhöht das Auftreten von BCC mit einer Latenz von 10 bis mehr als 50 Jahren nach Bestrahlung [9,15,24]. In einer prospektiven Studie konnte gezeigt werden, dass fast alle Gefäßmalformationen, auf denen BCC entstanden, in der Vergangenheit bestrahlt worden waren.…”

“…Die Gefäße des Naevus flammeus werden mit der Zeit ektatisch, die Läsion dunkler, und im Erwachsenenalter können knotige Formationen entstehen [15,24]. Deshalb kann es umso schwieriger sein, gerade in den knotigen Arealen eines Naevus flammeus ein BCC zu entdecken.…”

Basal cell carcinoma arising over facial port wine stain: a single‐centre experience

“…The majority of BCCs developing in PWS (around 75%) follow previous radiotherapy. There are only few cases of genuine BCCs in PWS with no previous radiotherapy 10,12,14,15,20 . PWS seems to be relatively immune to BCCs.…”

“…BCC arising in a PWS or nevus flammeus is a rare finding, although reports date back to the last quarter of the radiotherapy era 9–23 . The present prospective evaluation for the presence of signs of BCC in patients being treated in our centre for PWS was prompted by the increasing number of publications suggesting a connection between these entities.…”

Multiple Basal Cell Carcinomas Arising in a Port‐Wine Stain with a Remote History of Therapeutic Irradiation

“…Some authors have suggested that thorium X treatment may significantly contribute to the development of basal cell carcinoma within port‐wine stains (7, 8). Argon laser and Grenz ray also have been documented to predispose to basal cell carcinoma in port‐wine stains (9, 10). Nevertheless, a few reports of basal cell carcinoma arising within port‐wine stains without any previous therapy exist (11), and the mechanism of tumor development may involve an oncogenic factor, produced by the ecstatic vessels that make the overlying epidermis more susceptible to ultraviolet light or irradiation (11).…”