Basal forebrain cholinergic system volume is associated with general cognitive ability in the elderly

Lammers, Florian; Borchers, Friedrich; Feinkohl, Insa; Hendrikse, Jeroen; Kant, Ilse; Kozma, Petra; Pischon, Tobias; Slooter, Arjen J. C.; Spies, Claudia; Montfort, Simone J.T. van; Zacharias, Norman; Záborszky, László; Winterer, Georg

doi:10.1016/j.neuropsychologia.2018.08.005

Cited by 28 publications

(23 citation statements)

References 63 publications

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Section: Brain Morphologymentioning

confidence: 99%

“…The basal forebrain cholinergic system and its volume (BFCSV) has been suggested to be linked with general cognitive function [20] and the onset of MCI and dementia. However, Heinrich et al [12 ▪▪ ] found no association between BFCSV and preexisting NCD before surgery, suggesting that cognitive function depends on other relevant factors such as age, education and comorbidities besides BFCSV.…”

Section: Brain Morphologymentioning

confidence: 99%

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Risk assessment of perioperative neurocognitive disorders, where are we now?

Soehle

Coburn

2022

Current Opinion in Anaesthesiology

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Purpose of reviewPerioperative neurocognitive disorders (PNDs) are among the most frequent complications after surgery and are associated with considerable morbidity and mortality. We analysed the recent literature regarding risk assessment of PND. Recent findingsCertain genetic variants of the cholinergic receptor muscarinic 2 and 4, as well as a marked degree of frailty but not the kind of anaesthesia (general or spinal) are associated with the risk to develop postoperative delirium (POD). Models predict POD with a discriminative power, for example, area under the receiver operating characteristics curve between 0.52 and 0.94.

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Section: Brain Morphologymentioning

confidence: 99%

Section: Brain Morphologymentioning

confidence: 99%

Risk assessment of perioperative neurocognitive disorders, where are we now?

Soehle

Coburn

2022

Current Opinion in Anaesthesiology

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“…Six neuropsychological tests with a total of eight outcome measures were administered once at enrolment (T0) and again in identical form at 7 days (T1), and 3 months (T2) ( Table 1) [19]. Four tests were part of the Cambridge Neuropsychological Test Automated Battery (CANTAB; CANTAB Research Suite, Cambridge Cognition Ltd., UK) and were performed on touch-screen electronic devices with a press pad.…”

Section: Neuropsychological Assessmentmentioning

confidence: 99%

Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction

et al. 2020

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Objective: Studies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measurement imprecision, is often unclear. We determined the stability of a neuropsychological test battery using a sample of older adults from the general population. Forty-five participants aged 65 to 89 years performed six computerized and noncomputerized neuropsychological tests at baseline and again at 7 day and 3 months follow-up sessions. Mean scores on each test were compared across time points using repeated measures analyses of variance (ANOVA) with pairwise comparison. Two-way mixed effects, absolute agreement analyses of variance intra-class correlation coefficients (ICC) determined test-retest reliability.Results: All tests had moderate to excellent test-retest reliability during 7-day (ICC range 0.63 to 0.94; all p < 0.01) and 3-month intervals (ICC range 0.60 to 0.92; all p < 0.01) though confidence intervals of ICC estimates were large throughout. Practice effects apparent at 7 days eased off by 3 months. No substantial differences between computerized and non-computerized tests were observed. We conclude that the present six-test neuropsychological test battery is appropriate for use in POCD research though small sample size of our study needs to be recognized as a limitation.

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“…The battery consisted of 6 age-sensitive neuropsychological tests of which 4 (Paired Associates Learning; Verbal Recognition Memory; Spatial Span; Simple Reaction Time) were part of the CANTAB computerized battery and tapped the cognitive domains visual memory, verbal memory, working memory, and processing speed. Full details of the cognitive tests and testing procedure can be found elsewhere [20]. Two paper-pencil tests, Trail-Making Test-B and Grooved Pegboard, measuring executive function and fine motor skills, respectively, supplemented the battery.…”

Section: Cognitive Assessmentmentioning

confidence: 99%