Basal ganglia correlates of wellbeing in early adolescence

Boyes, Amanda; McLoughlin, Larisa T.; Anderson, Hannah; Schwenn, Paul; Shan, Zack; Gatt, Justine M.; Lagopoulos, Jim; Hermens, Daniel F.

doi:10.1016/j.brainres.2021.147710

Cited by 16 publications

(7 citation statements)

References 54 publications

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“…Similarly, anhedonia and lifetime major depressive disorder (MDD; negatively associated with wellbeing) are associated with smaller thalamus and nucleus accumbens volumes (Ancelin et al, 2019 ; Zhu et al, 2021 ). In terms of the caudate, a negative association between left caudate volume and subjective wellbeing ( n = 49, aged 12 years; Boyes et al, 2022 ) is supported by the current study.…”

Section: Discussionsupporting

confidence: 83%

Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image‐derived phenotypes in the UK Biobank

Jamshidi

Park

Montalto

et al. 2022

Human Brain Mapping

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Wellbeing, an important component of mental health, is influenced by genetic and environmental factors. Previous association studies between brain structure and wellbeing have typically focused on volumetric measures and employed small cohorts. Using the UK Biobank Resource, we explored the relationships between wellbeing and brain morphometrics (volume, thickness and surface area) at both phenotypic and genetic levels. The sample comprised 38,982 participants with neuroimaging and wellbeing phenotype data, of which 19,234 had genotypes from which wellbeing polygenic scores (PGS) were calculated. We examined the association of wellbeing phenotype and PGS with all brain regions (including cortical, subcortical, brainstem and cerebellar regions) using multiple linear models, including (1) basic neuroimaging covariates and (2) additional demographic factors that may synergistically impact wellbeing and its neural correlates. Genetic correlations between genomic variants influencing wellbeing and brain structure were also investigated. Small but significant associations between wellbeing and volumes of several cerebellar structures (β = 0.015-0.029, P FDR = 0.007-3.8 Â 10 À9 ), brainstem, nucleus accumbens and caudate were found. Cortical associations with wellbeing included volume of right lateral occipital, thickness of bilateral lateral occipital and cuneus, and surface area of left superior parietal, supramarginal and pre-/post-central regions. Wellbeing-PGS was associated with cerebellar volumes and supramarginal surface area. Small mediation effects of wellbeing phenotype and PGS on right VIIIb cerebellum were evident. No genetic correlation was found between wellbeing and brain morphometric measures. We provide a comprehensive overview of wellbeing-related brain morphometric variation. Notably, small effect sizes reflect the multifaceted nature of this concept.

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Section: Discussionsupporting

confidence: 83%

Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image‐derived phenotypes in the UK Biobank

Jamshidi

Park

Montalto

et al. 2022

Human Brain Mapping

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“…The integrity of white matter cortico-striatal connections in caudal-motor and adjacent striatal sub-regions (i.e., executive and temporal striatum) was reduced for PD patients relative to controls [101]. Interestingly, loneliness and human emotions are related to changes to the ventral striatum and cerebellum [57,102], while in adolescents, negative associations were found between left hemisphere caudate volume and scores on 'total wellbeing' [103].…”

Section: Discussionmentioning

confidence: 96%

Hemispheric Cortical, Cerebellar and Caudate Atrophy Associated to Cognitive Impairment in Metropolitan Mexico City Young Adults Exposed to Fine Particulate Matter Air Pollution

Calderón‐Garcidueñas

Hernández-Luna²,

Mukherjee

et al. 2022

Toxics

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Exposures to fine particulate matter PM2.5 are associated with Alzheimer’s, Parkinson’s (AD, PD) and TDP-43 pathology in young Metropolitan Mexico City (MMC) residents. High-resolution structural T1-weighted brain MRI and/or Montreal Cognitive Assessment (MoCA) data were examined in 302 volunteers age 32.7 ± 6.0 years old. We used multivariate linear regressions to examine cortical surface area and thickness, subcortical and cerebellar volumes and MoCA in ≤30 vs. ≥31 years old. MMC residents exposed to PM2.5 ~ 30.9 µg/m3. Robust hemispheric differences in frontal and temporal lobes, caudate and cerebellar gray and white matter and strong associations between MoCA total and index scores and caudate bilateral volumes, frontotemporal and cerebellar volumetric changes were documented. MoCA LIS scores are affected early and low pollution controls ≥ 31 years old have higher MoCA vs. MMC counterparts (p ≤ 0.0001). Residency in MMC is associated with cognitive impairment and overlapping targeted patterns of brain atrophy described for AD, PD and Fronto-Temporal Dementia (FTD). MMC children and young adult longitudinal studies are urgently needed to define brain development impact, cognitive impairment and brain atrophy related to air pollution. Identification of early AD, PD and FTD biomarkers and reductions on PM2.5 emissions, including poorly regulated heavy-duty diesel vehicles, should be prioritized to protect 21.8 million highly exposed MMC urbanites.

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“…This study has several limitations. First, previous studies have shown that a decrease in the left caudate nucleus volume is associated with improved well-being in adolescents and adults (Boyes et al 2022;Choi et al 2022). This nding contrasts with the results of this study, which found that a smaller left caudate may be protective against future risky behavior and reward-seeking.…”

Section: Limitationsmentioning

confidence: 99%

“…Several studies have shown that prosocial behavior is associated with enhanced subjective well-being (Martela and Ryan 2016), which describes people's overall evaluation of their quality of life, and typically includes life satisfaction, positive affect, and a lack of negative affect (Diener 1984). Recent neuroimaging studies using magnetic resonance imaging (MRI) have reported that the gray matter volume (GMV) of the left caudate is negatively associated with self-reported subjective well-being scores in adolescents and adults (Boyes et al 2022;Choi et al 2022), and the GMV of the right caudate is reduced in happy people who have a romantic partner relative to unhappy people who do not have a romantic partner (Kawamichi et al 2016). Furthermore, a previous intervention study showed that a veweek mindfulness training increased subjective well-being and reduced impulsivity.…”

Section: Introductionmentioning

confidence: 99%

Subjective well-being can be predicted by the caudate volume and promotion focus

Matsunaga,

Ohtsubo,

Ishii

et al. 2024

Preprint

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It is a well-known fact that the caudate nucleus is associated with motivational behaviors and subjective well-being. However, there are no longitudinal studies that have examined the relationship between brain structure, behavioral orientations, and subjective well-being. This study analyzes data from our previous longitudinal study to examine whether future subjective well-being can be predicted by the volume of the caudate nucleus. We also examined whether behavioral orientation, based on the regulatory focus theory showing two orientations: promotion and prevention focus, was related to the volume of the caudate nucleus. Voxel-based morphometry analysis indicated that the left caudate volume was positively associated with rating scores for future subjective well-being and promotion orientation. Furthermore, mediation analysis indicated that promotion orientation significantly mediated the relationship between future subjective well-being and left caudate volume. The findings indicate that future subjective well-being can be predicted by the volume of the left caudate nucleus, and that this relationship is mediated by promotion focus orientation.

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Basal ganglia correlates of wellbeing in early adolescence

Cited by 16 publications

References 54 publications

Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image‐derived phenotypes in the UK Biobank

Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image‐derived phenotypes in the UK Biobank

Hemispheric Cortical, Cerebellar and Caudate Atrophy Associated to Cognitive Impairment in Metropolitan Mexico City Young Adults Exposed to Fine Particulate Matter Air Pollution

Subjective well-being can be predicted by the caudate volume and promotion focus

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