Basal ganglia germinoma: Diagnostic value of MR spectroscopy and 11C-methionine positron emission tomography

Fujii, Yuji; Saito, Yoshiaki; Ogawa, Toshihide; Fujii, Shinya; Kamitani, Hideki; Kondo, Shinji; Horie, Yasushi; Togawa, Masami; Senda, Michio; Maegaki, Yoshihiro; Ohno, Kousaku

doi:10.1016/j.jns.2008.02.006

Cited by 19 publications

(18 citation statements)

References 16 publications

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“…STGC produce β-HCG; therefore, the detection of β-HCG in serum or cerebrospinal fluid (CSF) is an indicator of germinoma with STGC [8]. CNS germinomas are generally sensitive to radiotherapy and chemotherapy, and their 10-year survival rate is approximately 90 %; i.e., most of them are curable [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system

et al. 2013

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ObjectiveThe purpose of this study was to examine the 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) findings of central nervous system (CNS) germinoma and the diagnostic utility of these findings.MethodsWe retrospectively evaluated the cases of 10 patients who were diagnosed with CNS germinoma according to their histopathological or clinical findings. All the patients underwent pretreatment MET and/or FDG-PET scans, and the resultant images were assessed qualitatively and quantitatively. In the qualitative assessments, we used 3- and 5-grade visual scoring systems for the MET- and FDG-PET images, respectively. In the quantitative assessments, the maximal standardized uptake value (SUVmax) and the ratio of the SUVmax of the tumor (T) divided by the mean SUV for the normal white or gray matter [T/N (WM), T/N (GM)], was calculated.ResultsThe mean and SD values of SUVmax, T/N (WM), and T/N (GM) were 1.9 ± 1.4, 2.5 ± 1.3, and 1.7 ± 0.9 on MET-PET and 5.8 ± 2.2, 1.6 ± 0.5, and 0.8 ± 0.2 on FDG-PET, respectively. On MET-PET, only one lesion was not detected. On the other hand, on FDG-PET all of the lesions exhibited uptake values that were intermediate between those of the normal white matter and gray matter.ConclusionIn terms of its tumor-contouring ability, MET is a good tracer for diagnosing CNS germinomas; therefore, MET-PET is considered to be useful for planning biopsies or surgery. Although FDG-PET is capable of detecting CNS germinomas, it produced insufficient image contrast in the present study. Further studies are needed before FDG-PET can be used in clinical examinations of CNS germinoma.

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Section: Introductionmentioning

confidence: 99%

Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system

et al. 2013

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“…17 The clinical data and MR imaging findings of BG germinoma in the literature are summarized in Table 4, with only 1 previous article using the SWI technique. 18 Hence, we aimed to evaluate and compare SWI with conventional MR imaging in the diagnosis of early BG germinomas.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility-Weighted Imaging in the Diagnosis of Early Basal Ganglia Germinoma

Lou¹,

Ma²,

Wang³

et al. 2009

AJNR Am J Neuroradiol

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“…Erken dönem-de kolin/kreatinde artış görülmeyebilir. Takip görüntülerde kolin/kreatin oranındaki artış ile iskemik lezyondan ayrılırlar [9]. Bazal ganglia germinomlarının %33'üne serebral ve/veya beyin sapı atrofisi eşlik eder [7].…”

Section: Bazal Ganglion Germinomuunclassified

“…Bazal ganglia germinomlarının %33'üne serebral ve/veya beyin sapı atrofisi eşlik eder [7]. Aksonal transferrin transportununun invazyona sekonder engellenmesi ile ipsilateral globus pallidusta demir birikimine ait sinyal değişiklikleri görü-lebilir [9].…”

Section: Bazal Ganglion Germinomuunclassified

İntrakranyal Olgu Sunumlari

Bulut¹,

Akgöz²

2016

Trd Sem

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Basal ganglia germinoma: Diagnostic value of MR spectroscopy and 11C-methionine positron emission tomography

Cited by 19 publications

References 16 publications

Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system

Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system

Susceptibility-Weighted Imaging in the Diagnosis of Early Basal Ganglia Germinoma

İntrakranyal Olgu Sunumlari

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