2011
DOI: 10.1080/01652176.2011.570127
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Basal glucose metabolism and peripheral insulin sensitivity in equine pituitary pars intermedia dysfunction

Abstract: Background: Glucocorticoids are suggested to precipitate laminitis and induce insulin resistance in horses. Hypothesis/Objectives: To assess insulin sensitivity and the basal amount of glucose metabolized in equine pituitary pars intermedia dysfunction (PPID). Animals and methods: The euglycaemic hyperinsulinaemic clamp (EHC) technique was performed in seven horses with a diagnosis of PPID based on the presence of hypertrichosis and positive dexamethasone suppression-test results comprising one gelding and six… Show more

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Cited by 24 publications
(12 citation statements)
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“…These changes are seen in response to single and multiple doses of dexamethasone and begin within 2 h of administration with recovery taking up to 2 weeks after multiple dosing [22,24,25,27]. Similar increases in peripheral insulin resistance are seen in nonpregnant horses with hyperadrenocorticism induced by pars intermedia dysfunction [28]. In the current study, dexamethasone treatment of pregnant mares caused fasting hyperinsulinaemia, lactacidaemia and an enhanced pancreatic b cell response to exogenous glucose without any changes in glucose dynamics or fasting hyperglycaemia.…”
Section: Maternal Effectssupporting
confidence: 67%
“…These changes are seen in response to single and multiple doses of dexamethasone and begin within 2 h of administration with recovery taking up to 2 weeks after multiple dosing [22,24,25,27]. Similar increases in peripheral insulin resistance are seen in nonpregnant horses with hyperadrenocorticism induced by pars intermedia dysfunction [28]. In the current study, dexamethasone treatment of pregnant mares caused fasting hyperinsulinaemia, lactacidaemia and an enhanced pancreatic b cell response to exogenous glucose without any changes in glucose dynamics or fasting hyperglycaemia.…”
Section: Maternal Effectssupporting
confidence: 67%
“…Hyperinsulinaemic horses with normal body mass are more challenging to manage. The first question to be addressed is whether the animal is concurrently affected by PPID, so horses older than 10 years should undergo testing for both PPID and IR . Previously obese horses that remain hyperinsulinaemic after weight loss must also be managed carefully.…”
Section: Management Of Hyperinsulinaemia and Insulin Resistancementioning
confidence: 99%
“…However, it is unclear if the increased SAA is a cause or effects of the obesity and IR. In addition, previous reports have associated IR with pituitary pars intermedia lesions [11]- [13]. Horses with pituitary lesions have been shown to have increased body condition scores (BCS) [14].…”
Section: Introductionmentioning
confidence: 99%