Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance

Georgopoulos, Neoklis A.; Saltamavros, A.; Vervita, Vasiliki; Karkoulias, Kiriakos; Adonakis, George; Decavalas, George; Kourounis, George; Markou, Kostas B.; Kyriazopoulou, Venetsana

doi:10.1016/j.fertnstert.2008.04.067

Cited by 72 publications

(71 citation statements)

References 33 publications

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“…Therefore, the influence of the PPARg2 Pro12Ala SNP on BMR might be different among lean or obese subjects. Nevertheless, low BMR does not necessarily mean high BMI, as BMR values in obesity are reported within normal (18) or increased ranges (19), while we have recently shown decreased BMR in normal weight PCOS women (10). Nevertheless, the association of the Pro12Ala polymorphism with BMR was valid and in our subgroup of lean PCOS with BMI!25 kg/m 2 , excluding the confounding effect of obesity.…”

Section: Discussionmentioning

confidence: 49%

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Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

Koika¹,

Marioli²,

Saltamavros³

et al. 2009

European Journal of Endocrinology

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Objective: The peroxisome proliferator-activated receptor (PPAR)g is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARg2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARg2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women. Design: Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls. Methods: Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay. Results: Genotype frequencies of the Pro12Ala polymorphism in PPARg2 did not differ among PCOS women and control subjects.The presence of Pro12Ala polymorphism of PPARg2 was associated with lower BMR (PZ0.04). This finding was valid in our subgroup of lean PCOS (BMI!25 kg/m 2 ), in which the Ala variant was also associated with higher total testosterone values. Conclusion: The Pro12Ala polymorphism in the PPARg2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.

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Section: Discussionmentioning

confidence: 49%

“…This genotype has been associated with increased body mass index (BMI) and attenuated IR in PCOS (8,9). Moreover, we have recently shown that women with PCOS, particularly those with IR, present a significantly decreased BMR (10).…”

Section: Introductionmentioning

confidence: 96%

Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

Koika¹,

Marioli²,

Saltamavros³

et al. 2009

European Journal of Endocrinology

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“…Long cycles (32 days or longer) are usually associated with stress (emotional or physical). A systematic review [32] found that there is evidence that infertility has a negative effect on the psychological well-being and sexual relationships of couples, but the evidence is inconclusive for the effect on marital relationships and quality of life.…”

Section: Testes and Ovaries -Functional And Clinical Differences And mentioning

confidence: 99%

Introductory Chapter: One-Stop Infertility Evaluation Unit

Darwish¹,

Mohamed²

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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“…Obesity has been found to worsen the clinical and biochemical manifestations of PCOS. 1 Although some studies have suggested that women with PCOS have abnormalities in energy expenditure, due to reductions in resting metabolic rate 2 and postprandial thermogenesis, 3 these changes have not been detected in other studies. 4,5 The postprandial response of gastrointestinal hormones, part of the neural control of food intake, was shown to be lower in obese women with than without PCOS.…”

Section: Introductionmentioning

confidence: 96%

Imbalance Between Postprandial Ghrelin and Insulin Responses to an Ad Libitum Meal in Obese Women With Polycystic Ovary Syndrome

et al. 2014

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Obese women with polycystic ovary syndrome (PCOS) may have impairment in the regulation of food intake associated with ghrelin and insulin. In order to compare postprandial ghrelin and insulin responses to an ad libitum meal, we assessed 30 obese women with PCOS and 23 obese women without PCOS (control group). Blood samples were taken under fasting conditions, preprandially, and 15, 45, 75, and 135 minutes after the beginning of an ad libitum meal and ghrelin and insulin concentrations were analyzed. Insulin resistance (IR) was classified using basal insulin, quantitative insulin sensitivity check index, and homeostasis model assessment index. Mean ad libitum food intake was similar between the groups (468 + 150 vs 444 + 165 g, P ¼ .60). The IR was found in 56.6% in PCOS group compared with 30.4% in the control group (P < .01). The postprandial ghrelin response was similar in both the groups but the insulin area under the curve (AUC) tend to be greater in the PCOS group (12807 + 8149.4 vs 8654.4 + 7232.3 mIU/mL/min; P ¼ .057). The ghrelin AUC was negatively correlated with the insulin AUC (r ¼ À.5138; P ¼ .01) only in the control group. The imbalance in the feedback mechanisms between insulin and ghrelin, present in obese women, especially those with IR, may affect food intake throughout the day and that could be a mechanism for the development of obesity in PCOS.

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Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance

Cited by 72 publications

References 33 publications

Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

Introductory Chapter: One-Stop Infertility Evaluation Unit

Imbalance Between Postprandial Ghrelin and Insulin Responses to an Ad Libitum Meal in Obese Women With Polycystic Ovary Syndrome

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