Basal Prolactin and the Behaviour of the Gonadotrophins, Testosterone, Androstenedione, Estradiol, and the Sex-Hormone-Binding Globulin during Stimulation with Clomiphene in Subjects with Spermatogenic Disorders

Bolufer, Pascual; Rodrı́guez, A. O.; Antonio, Paulo; Bosch, Ernesto; Peiró, Teresa

doi:10.1055/s-0029-1210487

Cited by 4 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E2, P and T were quantified by RIA using tritium as tracer (Bolufer et al, 1983;Bolufer et al, 1985). The within-assay variability was 9,14 and 12% for E2, P and T, respectively.…”

Section: Determination Of Oestradiol Receptorsmentioning

confidence: 99%

Plasma Sex Steroids and SHBG in Patients with Breast Cancer and their Relation to Tumor Oestrogen-Dependency

Teruel¹,

Bolufer²,

Rodrı́guez³

et al. 2009

Exp Clin Endocrinol Diabetes

Self Cite

View full text Add to dashboard Cite

In order to evaluate the possible role of sex steroids in breast cancer and their relation to the presence of oestradiol receptors (ER), ER were quantified in 112 breast adenocarcinomas and 14 benign tumours. The sex hormones of the patients were determined in plasma: oestradiol (E2), progesterone, testosterone, androstenedione, as well as SHBG and gonadotrophins. The ER were evaluated in cytosolic and nuclear fractions. Steroids and gonadotrophins were determined by RIA. SHBG was determined by following a procedure of saturation with tritiated dihydrostestosterone. The mean levels of E2 in postmenopausal women with breast cancer was found to be significantly higher than of the control group. However, no significant variations for the rest of the steroids were seen among the patients with breast cancer and the control group or benign tumour. Nor was any relation found between the presence of ER and the hormonal steroids studied or SHBG. It is suggested that the possible influence of the sex steroids in the etiopathogenesis of breast cancer might be due to the greater production accompanied by a parallel metabolic clearance that would maintain their plasma levels.

show abstract

“…E2, P and T were quantified by RIA using tritium as tracer (Bolufer et al, 1983;Bolufer et al, 1985). The within-assay variability was 9,14 and 12% for E2, P and T, respectively.…”

Section: Determination Of Oestradiol Receptorsmentioning

confidence: 99%

Plasma Sex Steroids and SHBG in Patients with Breast Cancer and their Relation to Tumor Oestrogen-Dependency

Teruel¹,

Bolufer²,

Rodrı́guez³

et al. 2009

Exp Clin Endocrinol Diabetes

Self Cite

View full text Add to dashboard Cite

show abstract

Salivary testosterone levels in infertile men

Galard¹,

Antolı́n²,

Catalán³

et al. 1987

Int J of Andrology

View full text Add to dashboard Cite

Salivary testosterone levels were measured in 18 normal men, 29 oligospermic and six azoospermic subjects, using a specific and sensitive radioimmunoassay (RIA). There was a significant reduction (P less than 0.001) in salivary testosterone levels in the group of oligospermic (0.266 +/- 0.086 nmol/l) and azoospermic (0.234 +/- 0.055 nmol/l) subjects when compared with controls (0.348 +/- 0.070 nmol/l). A good correlation was found between salivary and plasma testosterone levels in normal (r = 0.62, P less than 0.01) and infertile men (r = 0.58, P less than 0.01). This study demonstrates that salivary testosterone levels, a non-invasive means of sample collection, may be used for evaluation of androgen status in male infertility.

show abstract

Impaired Leydig Cell Function in Infertile Men: A Study of 357 Idiopathic Infertile Men and 318 Proven Fertile Controls

Andersson

Jørgensen

Frydelund-Larsen

et al. 2004

The Journal of Clinical Endocrinology &Amp; Metabolism

218

140

View full text Add to dashboard Cite

To investigate whether an impaired Leydig cell function is present in severely oligospermic men, serum testosterone (T), LH, estradiol (E(2)), and SHBG levels in 357 idiopathic infertile men were compared with levels in 318 proven fertile men. In addition, the T/LH ratio, E(2)/T ratio, and calculated free T index (cFT) were compared between the two groups.A shift toward lower serum T levels, cFT, and T/LH ratio and higher serum LH, E(2), and E(2)/T levels was observed in the group of infertile men. On average, the infertile men had 18, 26, and 34% lower serum T, cFT, and T/LH levels, respectively, and 19, 18, and 33% higher serum LH, E(2), and E(2)/T levels, respectively, than the fertile men. Twelve percent of the infertile men had a serum T level that fell below the 2.5 percentile of the fertile levels, and 15% of the infertile men had a LH level that was above the 97.5 percentile of the fertile levels.Thus, the group of infertile men showed significant signs of impaired Leydig cell function in parallel to their impaired spermatogenesis. The association of decreased spermatogenesis and impaired Leydig cell function might reflect a disturbed paracrine communication between the seminiferous epithelium and the Leydig cells, triggered by distorted function of the seminiferous epithelium. On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development.

show abstract

Basal Prolactin and the Behaviour of the Gonadotrophins, Testosterone, Androstenedione, Estradiol, and the Sex-Hormone-Binding Globulin during Stimulation with Clomiphene in Subjects with Spermatogenic Disorders

Cited by 4 publications

References 5 publications

Plasma Sex Steroids and SHBG in Patients with Breast Cancer and their Relation to Tumor Oestrogen-Dependency

Plasma Sex Steroids and SHBG in Patients with Breast Cancer and their Relation to Tumor Oestrogen-Dependency

Salivary testosterone levels in infertile men

Impaired Leydig Cell Function in Infertile Men: A Study of 357 Idiopathic Infertile Men and 318 Proven Fertile Controls

Contact Info

Product

Resources

About