Basal Secretion of Digestive Enzymes in Old Age

Meyer, Jacob

doi:10.1001/archinte.1940.00190070181013

Cited by 33 publications

(17 citation statements)

References 8 publications

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“…These data confirm clini cal reports of suspected pancreatic insuffi ciency with aging [Meyer et al, 1940;Necheles et al, 1942].…”

Section: Discussionsupporting

confidence: 88%

“…Observations in individuals have suggested that fat malabsorption and pancreatic en zyme insufficiency may occur in some aging individuals [Meyer et al, 1940;Necheles et al, 1942;Becker et al, 1950;White et al, 1951;Garcia e\ al., 1955;Ryder, 1963;Web ster et al, 1977], In order to investigate this question, we studied pancreatic enzyme out put in the unanesthetized rat. We used rats of varying ages and assessed the influence of aging on basal pancreatic functions.…”

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confidence: 99%

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Aging-Associated Pancreatic Exocrine Insufficiency in the Unanesthetized Rat

Hollander

Dadufalza²

1984

Gerontology

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Observations in individuals have suggested that pancreatic functions may be diminished with aging. In order to explore this possibility, we measured pancreatic fluid, protein and amylase output as a function of aging in the rat. Surgical preparations of the rats included external drainage of pancreatic secretions without obstructing normal bile flow and complete diversion of gastric acid out of the duodenum to prevent endogenous secretin release. Pancreatic secretions were collected in the basal state in unanesthetized animals 24 h after surgery. Protein and amylase output were highest at 3 months of age and decreased to less than 20% of maximal values by 27 months of age. For example, amylase output decreased from 4,354 to 105 U/h/kg and protein output fell from 33.5 to 1.7 mg/h/kg between 3 and 27 months of age. Our findings indicate that aging in the rat is associated with diminished pancreatic exocrine functions. Further careful assessment of pancreatic functions in aging individuals is advisable.

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“…These data confirm clini cal reports of suspected pancreatic insuffi ciency with aging [Meyer et al, 1940;Necheles et al, 1942].…”

Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Aging-Associated Pancreatic Exocrine Insufficiency in the Unanesthetized Rat

Hollander

Dadufalza²

1984

Gerontology

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“…earlier studies done in America [11][12][13] and Japan [19]. In fact, the 1937 study by Meyer et al [11] stated that the average activity of the older group was only 3% that of the younger group.…”

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confidence: 98%

Salivary Amylase Activity of the Aged

Wang

Woolfolk²

1990

Gerontology

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Previous studies from America and Japan have reported that salivary amylase activity was reduced in the elderly. In contrast to these studies, a recent Chinese study reported an increase in salivary amylase activity in the aged. Our study examined approximately equal numbers of Chinese and non-Chinese Americans. The concentration of salivary amylase was estimated from the activity obtained with a colormetric coupled assay utilizing 4NP-G7. Activity was found to be increased in the aged. Our data are discussed with respect to the claims of the previous studies.

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“…It has been suggested that as part of the normal ageing process there are a number of changes which take place in the gastrointestinal tract, including reduced salivary secretion, reduced gastric acid secretion, decreased villus size and decreased cell turnover (Venn, 1992). One study (Meyer et al 1940) indicated that amylase (EC 3.2.1.1), trypsin (EC3.4.21.4) and lipase (EC 3.1.1.3) activities in fasting duodenal juice decline with age. However, the mammalian gastrointestinal tract has a large reserve capacity with respect to both digestion and absorption.…”

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confidence: 99%