Basal segment deep wedge resection for lung cancer with pulmonary fibrosis

Tane, Shinya; Ando, Yuko; Matsumoto, Gaku; Ueda, Shinsaku; Uchino, Kenji

doi:10.1007/s11748-021-01764-5

Cited by 1 publication

(2 citation statements)

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“… 33 Groups have described minimally invasive operative techniques as a means of mitigating the risk of postoperative AE. 38 The role of limited resection in this setting and its association with a lower rate of AE must be correlated with the poorer oncological outcomes and is indeed the focus of an ongoing randomised study. 39 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore intraoperative measures such as reducing the time on single-lung ventilation, avoiding fluid overload and hyperoxic time are also measures to be considered 33. Groups have described minimally invasive operative techniques as a means of mitigating the risk of postoperative AE 38. The role of limited resection in this setting and its association with a lower rate of AE must be correlated with the poorer oncological outcomes and is indeed the focus of an ongoing randomised study 39…”

Section: Discussionmentioning

confidence: 99%

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Lung cancer resection in patients with underlying usual interstitial pneumonia: a meta-analysis

et al. 2023

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ObjectivePatients with lung cancer with underlying idiopathic pulmonary fibrosis and usual interstitial pneumonia (UIP) pattern on CT represent a very high-risk group in terms of postoperative UIP acute exacerbations (AEs) and in-hospital mortality. We sought to investigate the outcomes in these patients.MethodsWe carried out a meta-analysis, searching four international databases from 1 January 1947 to 27 April 2022, for studies in any language reporting on the acute postoperative outcomes of patients with lung cancer undergoing surgical resection with underlying UIP (the primary outcome). Random effects meta-analyses (DerSimonian and Laird) were conducted. We analysed the difference in incidence of postoperative AE as well as the difference in long-term overall survival among subpopulations. These were stratified by the extent of surgical resection, with meta-regression testing (uniivariate and multivariate) according to the stage of disease, operative decision making and country of origin. This study was registered with PROSPERO (CRD42022319245).ResultsThe overall incidence of AE of UIP postoperatively from 10 studies (2202 patients) was 14.6% (random effects model, 95% CI 9.8 to 20.1, I2=74%). Sublobar resection was significantly associated with a reduced odds of postoperative AE (OR 0.521 (fixed effects model), 95% CI 0.339 to 0.803, p=0.0031, I2=0%). The extent of resection was not significantly associated with overall survival following lung cancer resection in UIP patients (HR for sublobar resection 0.978 (random effects model), 95% CI 0.521 to 1.833, p=0.9351, I2=71%).ConclusionsWith appropriate implementation of perioperative measures such as screening for high-risk cases, appropriate use of steroids, antifibrotics and employing sublobar resection in select cases, the risk of local recurrence versus in-hospital mortality from AEUIP can be balanced and long-term survival can be achieved in a super-selected group of patients. Further investigation in the form of a randomised study is warranted.

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Section: Discussionmentioning

confidence: 99%