Basal Septal Hypertrophy

Kelshiker, Mihir; Mayet, Jamil; Unsworth, Beth; Okonko, Darlington O.

doi:10.2174/1573403x09666131202125424

Cited by 31 publications

(28 citation statements)

References 33 publications

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“…This study identified a different pattern of hypertrophy characterized by isolated interventricular septal hypertrophy. Interventricular septal hypertrophy, particularly basal hypertrophy, is commonly associated with pressure overload disease including systemic hypertension in people and cats . In our study, the median SBP and the frequency of systemic hypertension were not significantly different between groups.…”

Section: Discussioncontrasting

confidence: 58%

“…Interventricular septal hypertrophy, particularly basal hypertrophy, is commonly associated with pressure overload disease including systemic hypertension in people and cats. 62,63 In our study, the median SBP and the frequency of systemic hypertension were not significantly different between groups. The small sample size and lack of power may have contributed to the lack of significance.…”

Section: Discussioncontrasting

confidence: 53%

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Cardiac and Metabolic Variables in Obese Dogs

Tropf

Nelson

Lee

et al. 2017

Veterinary Internal Medicne

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BackgroundThe etiology of obesity‐related cardiac dysfunction (ORCD) is linked to metabolic syndrome in people. Studies have indicated that obese dogs have components of metabolic syndrome, warranting evaluation for ORCD in obese dogs.ObjectivesTo evaluate cardiac structure and function and metabolic variables in obese dogs compared to ideal weight dogs.AnimalsForty‐six healthy, small‐breed (<25 pounds), obese dogs (n = 29) compared to ideal weight dogs (n = 17).MethodsA cross‐sectional study of cardiac structure and function by standard and strain echocardiographic measurements and quantification of serum metabolic variables (insulin:glucose ratios, lipid analysis, adiponectin, inflammatory markers).ResultsCompared to the ideal weight controls, obese dogs had cardiac changes characterized by an increased interventricular septal width in diastole to left ventricular internal dimension in diastole ratio, decreased ratios of peak early to peak late left ventricular inflow velocities, and ratios of peak early to peak late mitral annular tissue velocities, and increased fractional shortening and ejection fraction percentages. The left ventricular posterior wall width in diastole to left ventricular internal dimension in diastole ratios were not significantly different between groups. Systolic blood pressure was not significantly different between groups. Obese dogs had metabolic derangements characterized by increased insulin:glucose ratios, dyslipidemias with increased cholesterol, triglyceride, and high‐density lipoprotein concentrations, decreased adiponectin concentrations, and increased concentrations of interleukin 8 and keratinocyte‐derived chemokine‐like inflammatory cytokines.Conclusions and Clinical ImportanceCompared to ideal weight controls, obese dogs have alterations in cardiac structure and function as well as insulin resistance, dyslipidemia, hypoadiponectinemia, and increased concentrations of inflammatory markers. These findings warrant additional studies to investigate inflammation, dyslipidemia, and possibly systemic hypertension as potential contributing factors for altered cardiac function.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussioncontrasting

confidence: 53%

Cardiac and Metabolic Variables in Obese Dogs

Tropf

Nelson

Lee

et al. 2017

Veterinary Internal Medicne

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“…[ 6 ] Basal hypertrophy has been linked to long-standing hypertension, which was noted in our patient. [ 1 ] It is likely that Takotsubo developed in the setting of infection and surgery, and this, in turn, resulted in a decrease in the flow out of an already narrowed outflow tract. Conversely, sigmoid hypertrophy with catecholamine excess and hypovolemia contributes to a stress-induced cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 3 ] This disease entity can clinically manifest in patients with HCM but typically occurs more often with classic asymmetrical septal hypertrophy or the apical variant. [ 1 2 3 ] Our interesting case demonstrates this unique coexistence, and its recognition is critical for the management and treatment, especially in the setting of cardiogenic shock, as inotropic agents are likely to aggravate and worsen the clinical condition.…”

Section: Introductionmentioning

confidence: 90%

“…This condition is also called sigmoid hypertrophy and is associated with aging and chronic hypertension. [ 1 ] Takotsubo is a transient cardiomyopathy that occurs during periods of high physical or emotional stress. It typically presents with substernal chest pain, electrocardiogram changes which include ST elevation, ST depression, T-wave inversion, pathologic Q-waves and QT prolongation, shortness of breath, or cardiogenic shock.…”

Section: Introductionmentioning

confidence: 99%

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Takotsubo cardiomyopathy with basal hypertrophy and outflow obstruction in a patient with bowel ischemia

Abuarqoub

Garis

Shaaban

et al. 2018

Int J Crit Illn Inj Sci

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Basal septal hypertrophy is a rare and unique anatomical finding associated with hypertrophic cardiomyopathy (HCM). It is also described as a sigmoid hypertrophy and is linked with aging and chronic hypertension. Takotsubo cardiomyopathy is a transient cardiomyopathy that occurs during periods of high physical or emotional stress. Its occurrence with HCM is relatively common; however, this presentation occurs more often with the classic asymmetrical septal hypertrophy or the apical variant. This case demonstrates its coexistence with isolated sigmoid hypertrophy in an elderly, hypertensive female with severe ischemic bowel disease.

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Left Ventricular Septal Hypertrophy in Elderly Patients With Aortic Stenosis

Katayama

Panse

Kendall

et al. 2017

J of Ultrasound Medicine

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Objectives-Left ventricular (LV) septal hypertrophy in aortic stenosis raises diagnostic and therapeutic questions. However, the etiology and clinical consequences of this finding have not been well studied. The aim of this study was to perform a morphologic evaluation of the LV in aortic stenosis and to investigate the contributing factors and consequences of septal hypertrophy.Methods-Patients with moderate or severe aortic stenosis were prospectively enrolled. Patients with previous myocardial infarction, wall motion abnormalities, at least moderate valvular regurgitation, known cardiomyopathy, an LV ejection fraction of less than 50%, and age younger than 65 years were excluded.Results-Forty-one patients underwent a final analysis. Septal hypertrophy (LV septal wall thickness 15 mm) was confirmed in 21 of 41 patients. The septal hypertrophy group had higher peak aortic valve velocity, a higher diabetes mellitus rate, and a higher rate and longer duration of hypertension than those without septal hypertrophy. The peak aortic valve velocity (odds ratio, 7.1; 95% confidence interval, 1.4-37.1) and diabetes mellitus (odds ratio, 7.4; 95% confidence interval, 1.2-46.2) were the significant factors associated with septal hypertrophy by multivariate analysis. Intraventricular conduction disturbance on electrocardiography was more frequent in the septal hypertrophy group (P 5 .021).Conclusions-Left ventricular septal hypertrophy was commonly observed in elderly patients with aortic stenosis, and a higher aortic valve velocity, hypertension, and diabetes mellitus were associated factors. Intraventricular conduction disturbance occurred more often in patients with septal hypertrophy than those without, which implies the pathophysiologic consequence. Further studies are needed to determine the impact of septal hypertrophy and intraventricular conduction disturbance on the prognosis of patients after aortic valve interventions.Key Words-aortic stenosis; echocardiography (adult); electrocardiology; magnetic resonance imaging; valvular heart disease A symmetric hypertrophy, especially basal septal hypertrophy, has been identified as a variant in patients with aortic stenosis. However, the etiology and clinical consequences of this entity have not been well investigated: specifically, whether clinical factors such as hypertension, age, and the severity of aortic stenosis predispose patients to septal hypertrophy development and whether this hypertrophy has a causal effect for physiologic abnormalities. When septal thickness is excessive, differential diagnoses of hypertrophic cardiomyopathy or other infiltrative diseases need to be considered. Additionally, septal hypertrophy has an impact on clinical management that may dictate the choice of surgical procedure (traditional

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Basal Septal Hypertrophy

Cited by 31 publications

References 33 publications

Cardiac and Metabolic Variables in Obese Dogs

Cardiac and Metabolic Variables in Obese Dogs

Takotsubo cardiomyopathy with basal hypertrophy and outflow obstruction in a patient with bowel ischemia

Left Ventricular Septal Hypertrophy in Elderly Patients With Aortic Stenosis

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