Basaloid carcinoma of the lung: a really dismal histologic variant?

Kim, Dae Joon; Kim, Kil Dong; Shin, Dong Hwan; Ro, Jae Y.; Chung, Kwansoo

doi:10.1016/s0003-4975(03)01296-7

Cited by 49 publications

(37 citation statements)

References 9 publications

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“…Although the overall prevalence of basaloid carcinomas was 4.8%, consistent with data from the present study, even if slightly lower, the authors found no difference in survival and behaviour between BC and poorly differentiated SCC. However, as 14 of their 35 cases expressed at least one NE marker, two cases stained two NE markers, and one expressed synaptophysin but no CK 1, 5, 10 or 14, the series of KIM et al [16] could be suspected of including some large cell NE carcinoma. The present series remains the largest one reported with the longest median follow-up [7,16].…”

Section: Discussionmentioning

confidence: 92%

“…However, as 14 of their 35 cases expressed at least one NE marker, two cases stained two NE markers, and one expressed synaptophysin but no CK 1, 5, 10 or 14, the series of KIM et al [16] could be suspected of including some large cell NE carcinoma. The present series remains the largest one reported with the longest median follow-up [7,16]. Whereas the actuarial 5-yr survival rate of the present study's SCC group was equivalent to that observed by KIM et al [16], being 38 versus 40.6%, at 26 versus 36.5%, the BC group survival in the present series was clearly poorer than that reported in the same study [16].…”

Section: Discussionmentioning

confidence: 92%

“…However, a recent study published by KIM et al [16], based on 291 surgically resected lung tumours including 167 poorly differentiated SCC and 35 basaloid carcinomas compared in terms of clinical data and survival outcome, questioned their prognostic significance. Although the overall prevalence of basaloid carcinomas was 4.8%, consistent with data from the present study, even if slightly lower, the authors found no difference in survival and behaviour between BC and poorly differentiated SCC.…”

Section: Discussionmentioning

confidence: 99%

“…However, their prognostic significance has recently been questioned in a report based on a series of 35 basaloid carcinomas [16], which prompted the current authors to carry out a new analysis on a larger series of 90 cases with a longer follow-up. The previous observations are confirmed herein, and it is demonstrated that the basaloid pattern confers in itself a poor prognosis irrespective of the variant it belongs to, justifying the inclusion of the two lung carcinoma variants with a basaloid pattern within the same clinicopathological entity.…”

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confidence: 98%

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Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Moro-Sibilot¹,

Lantuéjoul²,

Diab³

et al. 2007

Eur Respir J

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Lung carcinoma with a basaloid pattern (BC) is classified as either a basaloid variant of squamous cell carcinoma (SCC) or as variant of large cell carcinoma (LCC) depending on the presence of a squamous component. In a previous study of 37 cases, the present authors showed that BC presented with a shorter median and overall survival.In order to confirm its clinical significance in a larger series, 90 BC, including 46 basaloid variants of LCC and 44 basaloid variants of SCC, were compared with 1,328 other nonsmall cell lung carcinoma (NSCLC) with regard to clinical features and survival.The survival of basaloid variants of LCC and SCC was comparable. Median and overall survival were significantly lower for BC than for NSCLC in stage I-II patients, with a median survival of 29 and 49 months, respectively, and 5-yr survival rates of 27 and 44% for BC and NSCLC. When disease-specific survival was considered, BC had a shorter survival than both NSCLC and SCC.Basaloid pattern confers a poor prognosis in nonsmall cell lung carcinoma, especially in stage I-II patients, suggesting that lung carcinoma with a basaloid pattern is not only a variant of squamous cell carcinoma or large cell carcinoma, but is a unique entity with a significantly poor prognosis.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

See 2 more Smart Citations

Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Moro-Sibilot¹,

Lantuéjoul²,

Diab³

et al. 2007

Eur Respir J

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“…Basaloid carcinoma is positive for 34bE12 and negative for TTF1 and neuroendocrine markers. [19][20][21] Knowing the pitfalls and merits of these markers is essential for correct interpretation. Adenocarcinomas positive for TTF1 or napsin A in the lung or extrapulmonary sites do not necessarily indicate a lung primary, because TTF1 þ or napsin A þ ADCs have been described in ADCs originating from other organs, particularly endometrial and endocervical ADCs, renal papillary or clear cell, and papillary thyroid carcinomas.…”

Section: Primary Lung Adc and Sccmentioning

confidence: 99%

Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update

Zhang

Deng

Cagle

2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry has become an indispensable ancillary tool for the accurate classification of pleuropulmonary and mediastinal neoplasms necessary for therapeutic decisions and predicting prognostic outcome in the era of personalized medicine. Diagnostic accuracy has significantly improved because of the continuous discoveries of tumor-associated biomarkers and the development of effective immunohistochemical panels.Objective.-To increase the accuracy of diagnosis and classify pleuropulmonary neoplasms through immunohistochemistry.Data Sources.-Literature review, authors' research data, and personal practice experience.Conclusions.-This review article has shown that appropriately selecting immunohistochemical panels enables pathologists to effectively diagnose most primary pleuropulmonary neoplasms and differentiate primary lung tumors from a variety of metastatic tumors to the lung. The discovery of new mutation-specific antibodies identifying a subset of specific gene-arranged lung tumors provides a promising alternative and cost-effective approach to molecular testing. Knowing the utilities and pitfalls of each tumor-associated biomarker is essential to avoiding potential diagnostic errors.

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Respiratory System

Hasleton¹,

Sloan²

2007

The Cancer Handbook

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The respiratory tract is a common site for cancer. Exposure to inhaled industrial and environmental particles, particularly those associated with smoking, is a major cause. Viruses also play a part, particularly the Epstein‐Barr virus (EBV) in nasopharyngeal carcinoma and human papillomavirus in squamous carcinomas of oropharynx, larynx, and bronchus. We focus on the more common and important cancers of the respiratory tract and give differential diagnoses where relevant. The World Health Organization has recently produced revised classifications of tumours of the respiratory tract (2004) and head and neck (2005). Sarcomatoid carcinoma has been added to the previously recognized squamous cell carcinoma, small cell carcinoma, adenocarcinoma, and large cell undifferentiated carcinoma of the lung in the new classification. Sinonasal undifferentiated carcinoma is also included as a recognized entity. It is increasingly recognized that precursor and early lesions are the best targets for interventions. Detection, biology, and current practice regarding assessment of precursor lesions are covered. It is increasingly recognized that many respiratory cancers arise in a field and second primaries with similar molecular features to the original tumour are being described.

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Basaloid carcinoma of the lung: a really dismal histologic variant?

Cited by 49 publications

References 9 publications

Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update

Respiratory System

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