Basaloid squamous carcinoma of oral cavity: a histologic and immunohistochemical study

Coletta, Ricardo D.; Cotrim, P.; Almeida, Oslei Paes de; Alves, Venâncio Avancini Ferreira; Wakamatsu, Alda; Vargas, Pablo Agustı́n

doi:10.1016/s1368-8375(02)00010-6

Cited by 58 publications

(44 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Differing dilutions of reagent may have been used, as the parameters were not published in the letter by those authors; also, there may have been variable amounts of basaloid and squamous components in the tumors used in our study compared to those two cases. It is noteworthy, though, that even focal positivity was diagnostically useful in this cytokeratin panel in including the diagnosis of BSCC, particularly since CK14 reactivity helps exclude neuroendocrine tumors and undifferentiated carcinomas [18,44].…”

Section: P-valuementioning

confidence: 96%

“…The first, proposed by Tellechea et al [16], used Ber-EP4 as a marker of BSCC, and this has been documented in other small series to be efficacious as well [8,9]. The second, proposed by Coletta et al [17,18], uses the combination of positive CK1 and positive CK14 with negative CK7. CK1 was reported positive only in the keratinizing component of the tumor, while CK14 was expected to be diffusely positive in the basaloid cells; negative CK7 staining was important to exclude adenoid cystic carcinoma or other salivary gland tumors.…”

Section: P-valuementioning

confidence: 99%

“…Immunohistochemistry has been utilized in an attempt to clarify this difficulty, but the results have been variable and sometimes conflicting [3,8,10,[12][13][14][15], with the exception of Ber-EP4, a monoclonal epithelial membrane antigen (EMA), which has demonstrated some specificity for BSCC in a few other studies [8,9,16]. Coletta et al also proposed a panel of three cytokeratin stains which were helpful in a series of five cases [17,18]. In this study we sought to test these two previously described stains in a larger number of cases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Winters

Naud

Evans

et al. 2008

Head and Neck Pathol

View full text Add to dashboard Cite

Diagnosis of basaloid squamous carcinoma (BSCC) currently relies mainly on histological criteria, with variable immunohistochemical results reported in small series. We explored the use of a battery of immunohistochemical stains to elucidate this diagnosis on 45 cases of BSCC. To further elucidate the immunohistochemical profile of BSCC, to explore potential genetic pathways of malignant transformation using proliferation markers, and to investigate a possible link with Human Papillomavirus (HPV). Forty-five cases of BSCC and 34 site-matched cases of squamous cell carcinoma (SCC) were obtained from the archives of the pathology department at our institution. Extensive literature review was undertaken utilizing Medline. Ber-EP4 is a useful diagnostic marker for BSCC, positive in 82% (37/45) of the cases and in 68% (23/34) of SCC. An alternative is the combination of cytokeratins CK14 and CK7, known to be negative, and CK1, known to be positive, which achieves an accuracy of 73% (33/45) in BSCC and 88% (30/34) in SCC. The two diagnostic approaches were in agreement in 66% of the cases; both methods were equally accurate in the divergent cases. Increased expression of the proliferation markers supports the concept that BSCC is a rapidly growing tumor. Results of p16 stains support an etiological link between BSCC and HPV; interestingly, HPV was present significantly more in BSCC (71% (32/45)), than in SCC (59% (20/34)) in this study (P=0.02).

show abstract

Section: P-valuementioning

confidence: 96%

Section: P-valuementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Winters

Naud

Evans

et al. 2008

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…13 Cell cultures and treatments NG fibroblasts (NG1 to NG5) were derived from healthy individuals (3 males and 2 females) with a mean age of 26.41 ± 4.52 years, who were submitted to procedures of tooth extraction. At the moment of the surgery, a fragment of the normal gingival tissue was removed and used for explant cultures.…”

Section: Immunohistochemical Analysismentioning

confidence: 99%

Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

et al. 2010

View full text Add to dashboard Cite

Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdifferentiation. The present study was undertaken to examine the in vivo and in vitro effect of CyA on myofibroblast transdifferentiation. Rats were treated for 60 days with a daily subcutaneous injection of CyA, and the gingival overgrowth tissue was analyzed by immunohistochemistry. In vitro, fibroblasts from normal gingiva (NG) were cultured in the presence of different concentrations of CyA, and subjected to semi-quantitative reverse transcriptase-polymerase chain reaction and western blot. Although CyA treatment stimulated TGF-β1 expression by NG fibroblasts, it lacked to induce expression and production of isoform α of smooth muscle actin (α-SMA), the specific myofibroblast marker. The expression levels of connective tissue growth factor (CTGF), which has been considered a key molecule to promote the transdifferentiation of myofibroblasts via TGF-β1 activation, were unaffected by CyA. Our results demonstrate that CyA-induced gingival overgrowth is not associated with activation of myofibroblast transdifferentiation, since CyA is not capable to increase CTGF expression.

show abstract

“…It has also been described in the nasal cavity, oesophagus, tonsil and oral cavity. 7,8,15,18 The histopathologic appearance and immunohistochemistry of BSCC are different from those of conventional SCC 5 and opinions vary as to its clinical behavior and prognosis compared with conventional SCC. 29 The aim of this paper is to report on 15 patients with BSCC in the oral and maxillofacial region and compare the clinical behavior and prognosis of BSCC and conventional SCC.…”

mentioning

confidence: 99%

A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region

Gao

Peng

et al. 2008

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Basaloid squamous carcinoma of oral cavity: a histologic and immunohistochemical study

Cited by 58 publications

References 26 publications

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Ber-EP4, CK1, CK7 and CK14 are Useful Markers for Basaloid Squamous Carcinoma: A Study of 45 Cases

Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region

Contact Info

Product

Resources

About