Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall

Khaldi, Lubna; Apostolidis, Theodoros Ch.; Pappa, Dimitra; Apostolidis, Maria Th.; Apostolidis, Theocharis I.

doi:10.1016/j.anndiagpath.2005.09.011

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…[6] BSC arises from totipotential cells, which are also a precursor of squamous carcinoma, adenocarcinoma, oat cell carcinoma and reverse cell carcinoma. [7] Basaloid squamous carcinoma of SGL predominantly affects males in the sixth or seventh decades of life. [8] However, in the present case, the patient was in fourth decade of life.…”

Section: Discussionmentioning

confidence: 99%

Basaloid squamous carcinoma of the supraglottic larynx with neuro-endocrine features

Das

Sarma

Krishnatreya

et al. 2015

Clin Cancer Investig J

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Basaloid squamous carcinoma (BSC) is a rare aggressive variant of squamous cell carcinoma and occurs mainly at the larynx, oropharynx and tongue of the head and neck region. Neuro-endocrine differentiation of BSC is further rare occurrence in laryngeal cancers. We report here a case of BSC of supraglottic larynx with neuro-endocrine differentiation, which was treated by radiotherapy and its response to treatment.

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Section: Discussionmentioning

confidence: 99%

Basaloid squamous carcinoma of the supraglottic larynx with neuro-endocrine features

Das

Sarma

Krishnatreya

et al. 2015

Clin Cancer Investig J

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“…6 Although alcohol and tobacco use plays a role in the etiology of some cases of BSCC, HPV and HSV are more commonly involved. 7,8 The differential diagnoses include squamous cell carcinoma, small-cell neuroendocrine carcinoma, adenoid carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, spindle-cell squamous cell carcinoma, and mucoepidermoid carcinoma. 9,10 Adenoid carcinoma and small-cell undifferentiated carcinomas can be differentiated by immunohistochemical techniques.…”

Section: Discussionmentioning

confidence: 99%

Basaloid Squamous Cell Carcinoma of the Larynx: Case Report

Berkıten¹,

Mutlu²,

Kumral³

et al. 2015

Turkiye Klinikleri J Case Rep

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Basaloid squamous cell carcinoma (BSCC) is a high-grade variant of squamous cell carcinoma that comprises several subtypes, such as verrucous, spindle cell, and basaloid carcinoma. BSCC is a rare, aggressive variant that is characterized by proliferation of basaloid cells and intimately associated with squamous cell carcinoma, dysplasia, or focal squamous differentiation.1 BSCC is localized in mainly the head and neck region. The most frequent localization in the upper aerodigestive tract is the oropharynx (base of the tongue), hypopharynx (pyriform sinus), and supraglottic larynx. , which is a high-grade and rare variant of squamous cell carcinoma, is often located in the head and neck region. It is usually localized in the oropharynx (base of the tongue), hypopharynx (pyriform sinus), and supraglottic laryngeal regions of the upper aerodigestive tract. It is characterized as clinically aggressive and usually diagnosed in its advanced stage as distant metastases. Therefore, aggressive surgical intervention is essential. A 55-year-old patient with a diagnosis of laryngeal squamous cell carcinoma underwent total laryngectomy and bilateral neck dissection because of disease recurrence after radiotherapy. Histological examination revealed the presence of a basaloid squamous cell carcinoma of the larynx. Chemotherapy was planned because of laryngeal recurrence. In our case report, a rare variant (poorly differentiated BSCC of the larynx) is presented with a review of the relevant literature.

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“…Recebem o nome de tumores malignos epiteliais basalóides porque apresentam algumas características histopatológicas comuns, como: padrão sólido de crescimento; presença de ilhas formadas por células malignas organizadas em paliçada na periferia; pela presença de células basalóides que apresentam núcleos hipercromáticos e citoplasma escasso; e comedonecrose (necrose coagulativa central) na região central de ilhas ou lóbulos tumorais. Embora sejam muito semelhantes na histopatologia, os tumores malignos basalóides se diferenciam no comportamento clínico, assim, alguns autores reforçam a importância em estabelecer um correto diagnóstico, com tratamento e prognóstico compatíveis (Coletta et al, 2001;Coletta et al, 2006;Khaldi et al, 2006;Soriano et al, 2008).…”

Section: Epidemiologia Do Câncerunclassified

“…Tumores como o CEC-pd, o CEB, e o CAC-sólido apresentam essas características histopatológicas e são considerados neoplasias malignas epiteliais basalóides. Esses tumores merecem atenção, pois embora apresentem semelhanças histopatológicas, apresentam diferenças relacionadas ao comportamento clínico, protocolo de tratamento e prognóstico (Coletta et al, 2001;Coletta et al, 2006;Khaldi et al, 2006;Soriano et al, 2008).…”

Section: Epidemiologia Do Câncerunclassified

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Estudo da expressão imunoistoquimica de KI-67, Mcm-2 e HOXB7 em neoplasias basaloides de cabeça e pescoço

Rocha¹,

Vargas²

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Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall

Cited by 13 publications

References 18 publications

Basaloid squamous carcinoma of the supraglottic larynx with neuro-endocrine features

Basaloid squamous carcinoma of the supraglottic larynx with neuro-endocrine features

Basaloid Squamous Cell Carcinoma of the Larynx: Case Report

Estudo da expressão imunoistoquimica de KI-67, Mcm-2 e HOXB7 em neoplasias basaloides de cabeça e pescoço

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