Basaloid squamous cell carcinoma of esophagus expressing KIT: A case report with immunohistochemical analysis

Abstract

Basaloid squamous cell carcinoma of esophagus (BSCC-E) is rare. This case report is the first demonstrating KIT protein expression of BSCC-E. A 74-year-old man presented with dysphagia. Endoscopy revealed a polypoid tumor (2 × 2 × 2.5 cm) with a stalk in cervical esophagus. Biopsy showed squamous cell carcinoma with undifferentiated areas. An endoscopic submucosal dissection (ESD) was performed. Grossly, it was solid tumor with white cut surface. Histologically, the tumor was hypercellular carcinoma consisting of solid areas of island. The tumor cells were composed of basaloid malignant cells with hyperchromatic nuclei, scant cytoplasm, and basophilic cytoplasm. Many mitotic figures were recognized. Foci of comedonecrosis were scattered. Areas of squamous and glandular differentiations were scattered. Immunohistochemically, the tumor cells were positive for pancytokeratin (PCK) CAM5.2, PCK AE1/3, cytokeratin (CK) 7, KIT, CEA, CA19-9, EMA, Ki-67 (labeling index = 80%). The tumor cells were negative for CK20, PDGFRA, NSE, vimentin, estrogen receptor, p53 protein, chromogranin, synaptophysin, CD56, and TTF-1.

Non-Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterectomy

“…2017; 10(6):e9301. (EMA), cytokeratin-34βE12 (CK 34BE12) whereas negative for p63 protein, chromogranin, synaptophysin, platelet derived growth factor receptor (PDGFRA), estrogen receptor (ER), cluster of differentiation-56 ( CD56), and thyroid transcription factor-1(TTF-1) (7,17). In agreement with earlier studies, the tumor cells in our case stained negative for P53, chromogranin, synaptophysin while positive for CK AE1/AE3 and EMA.…”

Basaloid Squamous Cell Carcinoma of Oesophagus: Definitely Rare but does it Differs Significantly from the Conventional Squamous Cell Carcinoma.

“…Tadashi tereda et al mentioned in their study that diagnosing BSCC on small biopsies are very difficult and we believe the statement is true. 13 Both the cases in our study were falsely diagnosed as moderately differentiated squamous cell carcinoma on small biopsies which were reported in other institutes. Most important reason is the size of the biopsy which affects the assessment of the characteristic cytoarchitectural pattern and hence could lead a pathologist to pen down an inappropriate diagnosis.…”

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

“…Some immunohistochemical (IHC) markers are used for its finding -among them: CK-AE1/AE 3, cytokeratin-7 (CK7), tyrosine-proteinkinase (C-KIT), carcinogenic embryogenic antigen (CEA), cancer antigen 19-9 (CA19-9), epithelial membrane antigen (EMA), cytokeratin-34β 12 (CK 34BE12), p63 protein, chromogranin, synaptophysin, platelet-derived growth factor receptor (PDGFRA), oestrogen receptor (ER), cluster of differentiation-56 (CD56), and thyroid transcription factor-1 (TTF-1). 2,14 For some of them BSCC is positive, and for others -negative.…”